PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA
<span style="font-size: 12.0pt; font-family: " lang="EN-US">We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder.<span style="mso-spacerun: yes;"> </span>The p...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2010-05-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/article/view/6207 |
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| author | Lynn C. Moscinski Mark E. Johns Lubomir Sokol |
| author_facet | Lynn C. Moscinski Mark E. Johns Lubomir Sokol |
| author_sort | Lynn C. Moscinski |
| collection | DOAJ |
| description | <span style="font-size: 12.0pt; font-family: " lang="EN-US">We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder.<span style="mso-spacerun: yes;"> </span>The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan.<span style="mso-spacerun: yes;"> </span>Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant immunophenotype.<span style="mso-spacerun: yes;"> </span>Additionally,<span style="background: white;"> a TCR beta gene was found to be clonally rearranged in both peripheral blood and bone marrow supporting a clonal origin of atypical T cells. However, </span>no such clonal population of T-cells could be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes. After discontinuing the patient’s phenytoin, his lymphadenopathy has nearly completely resolved and circulation clonal T cell population disappeared with 12 months of follow-up.<br style="mso-special-character: line-break; page-break-before: always;" /></span> |
| format | Article |
| id | doaj-art-54afd88d7a3a47e894d35d9cd4e21cee |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-54afd88d7a3a47e894d35d9cd4e21cee2025-08-20T02:08:32ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-05-0122e2010028e2010028PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMALynn C. MoscinskiMark E. JohnsLubomir Sokol<span style="font-size: 12.0pt; font-family: " lang="EN-US">We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder.<span style="mso-spacerun: yes;"> </span>The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan.<span style="mso-spacerun: yes;"> </span>Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant immunophenotype.<span style="mso-spacerun: yes;"> </span>Additionally,<span style="background: white;"> a TCR beta gene was found to be clonally rearranged in both peripheral blood and bone marrow supporting a clonal origin of atypical T cells. However, </span>no such clonal population of T-cells could be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes. After discontinuing the patient’s phenytoin, his lymphadenopathy has nearly completely resolved and circulation clonal T cell population disappeared with 12 months of follow-up.<br style="mso-special-character: line-break; page-break-before: always;" /></span>http://www.mjhid.org/article/view/6207Lymphoma, psedolymphoma, Phenitoine |
| spellingShingle | Lynn C. Moscinski Mark E. Johns Lubomir Sokol PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA Mediterranean Journal of Hematology and Infectious Diseases Lymphoma, psedolymphoma, Phenitoine |
| title | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_full | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_fullStr | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_full_unstemmed | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_short | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_sort | phenytoin associated lymphoadenopathy mimicking a peripheral t cell lymphoma |
| topic | Lymphoma, psedolymphoma, Phenitoine |
| url | http://www.mjhid.org/article/view/6207 |
| work_keys_str_mv | AT lynncmoscinski phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma AT markejohns phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma AT lubomirsokol phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma |