Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review

Primary endometrial squamous cell carcinoma (PESCC) is a rare pathology. Data regarding diagnosis and treatment is limited and is solely based on case reports and series. We report a unique case of a postmenopausal woman with a history of HIV and anal cancer s/p radiation therapy 8 years prior. The...

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Main Authors: Judy Hayek, Mariem Del Rio, Yongmei Yin, Margaux J. Kanis
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/crog/7140494
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author Judy Hayek
Mariem Del Rio
Yongmei Yin
Margaux J. Kanis
author_facet Judy Hayek
Mariem Del Rio
Yongmei Yin
Margaux J. Kanis
author_sort Judy Hayek
collection DOAJ
description Primary endometrial squamous cell carcinoma (PESCC) is a rare pathology. Data regarding diagnosis and treatment is limited and is solely based on case reports and series. We report a unique case of a postmenopausal woman with a history of HIV and anal cancer s/p radiation therapy 8 years prior. The patient’s presenting diagnosis was malodorous vaginal discharge refractory to antibiotics. The patient had a significant delay in diagnosis since the onset of symptoms despite extensive workup but eventually underwent surgical staging by gynecologic oncology with a diagnosis of Stage IB PESCC. Despite her reported history of anal cancer for which she received an incomplete course of pelvic radiation, the case was discussed at tumor board and the patient was deemed a candidate for external beam radiation therapy. In our report, we discuss, in detail, the patient’s presentation, course, and treatment and review the literature.
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spelling doaj-art-54af30eab92e43bfbdfaaa60744eda212025-08-20T03:22:15ZengWileyCase Reports in Obstetrics and Gynecology2090-66922025-01-01202510.1155/crog/7140494Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature ReviewJudy Hayek0Mariem Del Rio1Yongmei Yin2Margaux J. Kanis3Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of PathologyDivision of Gynecologic OncologyPrimary endometrial squamous cell carcinoma (PESCC) is a rare pathology. Data regarding diagnosis and treatment is limited and is solely based on case reports and series. We report a unique case of a postmenopausal woman with a history of HIV and anal cancer s/p radiation therapy 8 years prior. The patient’s presenting diagnosis was malodorous vaginal discharge refractory to antibiotics. The patient had a significant delay in diagnosis since the onset of symptoms despite extensive workup but eventually underwent surgical staging by gynecologic oncology with a diagnosis of Stage IB PESCC. Despite her reported history of anal cancer for which she received an incomplete course of pelvic radiation, the case was discussed at tumor board and the patient was deemed a candidate for external beam radiation therapy. In our report, we discuss, in detail, the patient’s presentation, course, and treatment and review the literature.http://dx.doi.org/10.1155/crog/7140494
spellingShingle Judy Hayek
Mariem Del Rio
Yongmei Yin
Margaux J. Kanis
Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
Case Reports in Obstetrics and Gynecology
title Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
title_full Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
title_fullStr Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
title_full_unstemmed Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
title_short Primary Squamous Cell Carcinoma of the Uterus and Not the Cervix—A Case Report and Literature Review
title_sort primary squamous cell carcinoma of the uterus and not the cervix a case report and literature review
url http://dx.doi.org/10.1155/crog/7140494
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