Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology

Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology

Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks of Alzheimer's disease. Here, we aimed to investigate the temporal and spatial association between synaptic activity, Aβ plaque load, and neuroinflammation in an Aβ mouse model with limited...

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Bibliographic Details
Main Authors: L.H. Kunze, G. Palumbo, J. Gnörich, K. Wind-Mark, R. Schaefer, S. Lindner, F.-J. Gildehaus, S. Ziegler, M. Brendel
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:NeuroImage
Subjects:
Synaptic density
Alzheimer's disease
SV2A-PET
β-amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811925001673
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