ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

Abstract Embryonal tumor with multilayered rosettes (ETMR) is a lethal embryonal brain tumor entity. To investigate the intratumoral heterogeneity and cellular communication in the tumor microenvironment (TME), we analyze in this work single-cell RNA sequencing of about 250,000 cells of primary huma...

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Main Authors: Flavia W. de Faria, Nicole C. Riedel, Daniel Münter, Marta Interlandi, Carolin Göbel, Lea Altendorf, Mathis Richter, Viktoria Melcher, Christian Thomas, Rajanya Roy, Melanie Schoof, Ivan Bedzhov, Natalia Moreno, Monika Graf, Marc Hotfilder, Dörthe Holdhof, Wolfgang Hartmann, Ann-Katrin Bruns, Angela Brentrup, Friederike Liesche-Starnecker, Bruno Maerkl, Sarah Sandmann, Julian Varghese, Martin Dugas, Pedro H. Pinto, Sebastian T. Balbach, I-Na Lu, Claudia Rossig, Oliver Soehnlein, Aysegül Canak, Martin Ebinger, Martin Schuhmann, Jens Schittenhelm, Michael F. Frühwald, Ulrich Schüller, Thomas K. Albert, Carolin Walter, Jan M. Bruder, Kornelius Kerl
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60442-9
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