Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis

Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis

Abstract Background Colorectal cancer (CRC) is a prevalent global malignancy where gut microbiota plays a key role. Streptococcus gallolyticus (Sg), a gut commensal and opportunistic pathogen, is associated with CRC. This study investigates the impact of the supernatant derived from Sg cultures (her...

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Main Authors: Jiaqi Wang, Yan Zhang, Duo Luo, Jing Xu, Xin Nie, Chen Huang, Hailan Zhao, Minzheng Zhu, Xue Guo, Yong Zhang, Wenjing Qiu, Haoming Xu, Yuqiang Nie, Youlian Zhou
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Gut Pathogens
Subjects:
Colorectal neoplasms
Gut microbiota
Streptococcus Gallolyticus
Macrophages
IL-17
Online Access:https://doi.org/10.1186/s13099-025-00731-2
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