Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse model of Heligmosomoides polygyrus infection...

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Bibliographic Details
Main Authors:	James P Hewitson, Kara J Filbey, Julia Esser-von Bieren, Mali Camberis, Christian Schwartz, Janice Murray, Lisa A Reynolds, Natalie Blair, Elaine Robertson, Yvonne Harcus, Louis Boon, Stanley Ching-Cheng Huang, Lihua Yang, Yizheng Tu, Mark J Miller, David Voehringer, Graham Le Gros, Nicola Harris, Rick M Maizels
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-03-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1004676
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Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

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