Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status
Abstract Background Streptococcus pneumoniae infections continue to pose significant health risks, particularly in adults with underlying conditions. This study assesses both demographic and clinical profiles of adult patients with invasive and non-invasive pneumococcal diseases, focusing on their v...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-10579-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197606555353088 |
|---|---|
| author | Hasip Kahraman Pınar Yıldız Şenay Yılmaz Gül Durmaz Muzaffer Bilgin Derya Çağlayan |
| author_facet | Hasip Kahraman Pınar Yıldız Şenay Yılmaz Gül Durmaz Muzaffer Bilgin Derya Çağlayan |
| author_sort | Hasip Kahraman |
| collection | DOAJ |
| description | Abstract Background Streptococcus pneumoniae infections continue to pose significant health risks, particularly in adults with underlying conditions. This study assesses both demographic and clinical profiles of adult patients with invasive and non-invasive pneumococcal diseases, focusing on their vaccination status and outcomes. Methods We retrospectively analyzed clinical data from 217 adults diagnosed with pneumococcal infections at Eskişehir Osmangazi University Faculty of Medicine, a tertiary-care university hospital in Eskişehir, Türkiye, from January 2016 to November 2023. Cases meeting specific clinical and microbiological criteria were included. Logistic regression was utilized to identify key predictors of mortality. Results Of the 217 patients initially screened, 155 were included in the final analysis, comprising 75 cases of invasive and 80 cases of non-invasive disease. Notably, among those recommended for pneumococcal vaccination, only 20.6% were vaccinated, and strikingly, only 9% were vaccinated before infection. Significant correlations were observed between mortality and various factors, including age, comorbidities, bacteremia, invasive disease, and intensive care unit admissions. Mortality occurred in 39 (25.2%) of the patients, with notably higher risks among those with comorbidities and requiring intensive care. Conclusion Pneumococcal infections continue to impose a significant health burden, particularly among older adults and those with pre-existing conditions. Our findings highlight the critical role of comorbidities and intensive care unit admissions in affecting patient outcomes, stressing the importance of timely interventions and enhanced health strategies to improve vaccination rates and overall outcomes in high-risk populations. |
| format | Article |
| id | doaj-art-548fc73296cb4e4cb47e6a54336eea91 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-548fc73296cb4e4cb47e6a54336eea912025-02-09T12:14:42ZengBMCBMC Infectious Diseases1471-23342025-02-012511810.1186/s12879-025-10579-1Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination statusHasip Kahraman0Pınar Yıldız1Şenay Yılmaz2Gül Durmaz3Muzaffer Bilgin4Derya Çağlayan5Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Eskisehir Osmangazi UniversityDepartment of Internal Medicine, Faculty of Medicine, Eskisehir Osmangazi UniversityDepartment of Chest Disease, Faculty of Medicine, Eskisehir Osmangazi UniversityDepartment of Clinical Microbiology, Faculty of Medicine, Eskisehir Osmangazi UniversityDepartment of Biostatistics, Faculty of Medicine, Eskişehir Osmangazi UniversityDiyarbakir Provincial Health Department, Division of Communicable DiseasesAbstract Background Streptococcus pneumoniae infections continue to pose significant health risks, particularly in adults with underlying conditions. This study assesses both demographic and clinical profiles of adult patients with invasive and non-invasive pneumococcal diseases, focusing on their vaccination status and outcomes. Methods We retrospectively analyzed clinical data from 217 adults diagnosed with pneumococcal infections at Eskişehir Osmangazi University Faculty of Medicine, a tertiary-care university hospital in Eskişehir, Türkiye, from January 2016 to November 2023. Cases meeting specific clinical and microbiological criteria were included. Logistic regression was utilized to identify key predictors of mortality. Results Of the 217 patients initially screened, 155 were included in the final analysis, comprising 75 cases of invasive and 80 cases of non-invasive disease. Notably, among those recommended for pneumococcal vaccination, only 20.6% were vaccinated, and strikingly, only 9% were vaccinated before infection. Significant correlations were observed between mortality and various factors, including age, comorbidities, bacteremia, invasive disease, and intensive care unit admissions. Mortality occurred in 39 (25.2%) of the patients, with notably higher risks among those with comorbidities and requiring intensive care. Conclusion Pneumococcal infections continue to impose a significant health burden, particularly among older adults and those with pre-existing conditions. Our findings highlight the critical role of comorbidities and intensive care unit admissions in affecting patient outcomes, stressing the importance of timely interventions and enhanced health strategies to improve vaccination rates and overall outcomes in high-risk populations.https://doi.org/10.1186/s12879-025-10579-1Pneumococcal infectionsInvasive pneumococcal diseaseAdult immunizationPublic health |
| spellingShingle | Hasip Kahraman Pınar Yıldız Şenay Yılmaz Gül Durmaz Muzaffer Bilgin Derya Çağlayan Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status BMC Infectious Diseases Pneumococcal infections Invasive pneumococcal disease Adult immunization Public health |
| title | Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status |
| title_full | Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status |
| title_fullStr | Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status |
| title_full_unstemmed | Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status |
| title_short | Impact of invasive and noninvasive pneumococcal diseases on adult populations: risk factors and vaccination status |
| title_sort | impact of invasive and noninvasive pneumococcal diseases on adult populations risk factors and vaccination status |
| topic | Pneumococcal infections Invasive pneumococcal disease Adult immunization Public health |
| url | https://doi.org/10.1186/s12879-025-10579-1 |
| work_keys_str_mv | AT hasipkahraman impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus AT pınaryıldız impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus AT senayyılmaz impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus AT guldurmaz impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus AT muzafferbilgin impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus AT deryacaglayan impactofinvasiveandnoninvasivepneumococcaldiseasesonadultpopulationsriskfactorsandvaccinationstatus |