Infectious complications distribution following CLL1 CAR-T cell therapy for acute myeloid leukemiass

Infectious complications distribution following CLL1 CAR-T cell therapy for acute myeloid leukemiass

Abstract The CLL1-targeted chimeric antigen receptor T (CAR-T) cell therapy offers a novel therapeutic approach for refractory or relapsed acute myeloid leukemia (AML).The targeted elimination of tumor cells by CLL1 CAR-T therapy also induces cytotoxic effects on neutrophils, leading to a severe gra...

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Bibliographic Details
Main Authors: Jianmei Xu, Huan Zhang, Yifan Zhao, Xiaomei Zhang, Shujing Guo, Xiaoxue Shi, Xia Xiao, Hairong Lyu, Yu Zhang, Xiaoyuan He, Mingfeng Zhao
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Infection
Prevention
CLL1 CAR-T
Cytokine release syndrome
Acute myeloid leukemia
Online Access:https://doi.org/10.1007/s00262-025-03998-1
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