Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study
Background: Non-immunoglobulin E-mediated gastrointestinal food allergies (non-IgE-GI-FAs) in children with Down syndrome (DS) tend to be more severe, with some children presenting with sepsis-like symptoms. However, the epidemiology of this condition remains unknown. This study aimed to investigate...
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Elsevier
2025-08-01
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| Series: | World Allergy Organization Journal |
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| author | Fumiko Okazaki, MD Hiroyuki Wakiguchi, MD, PhD Yuno Korenaga, MD Mototsugu Shimokawa, PhD Tsuyoshi Tanabe, MD, PhD Ken Fukuda, MD, PhD Masanari Hasegawa, MD, PhD Miho Shimizu, MD, PhD Reiji Hirano, MD, PhD Tadashi Moriwake, MD, PhD Mai Kawamura, MD Hiroshi Tateishi, MD, PhD Ryo Kadoya, MD, PhD Yasumasa Tsuda, MD Takaomi Sekino, MD, PhD Norimichi Tashiro, MD, PhD Hirofumi Inoue, MD, PhD Yoshiko Nawata, MD Makoto Mizutani, MD, PhD Takashi Maki, MD Kenji Nakatsuka, MD, PhD Shunji Hasegawa, MD, PhD |
| author_facet | Fumiko Okazaki, MD Hiroyuki Wakiguchi, MD, PhD Yuno Korenaga, MD Mototsugu Shimokawa, PhD Tsuyoshi Tanabe, MD, PhD Ken Fukuda, MD, PhD Masanari Hasegawa, MD, PhD Miho Shimizu, MD, PhD Reiji Hirano, MD, PhD Tadashi Moriwake, MD, PhD Mai Kawamura, MD Hiroshi Tateishi, MD, PhD Ryo Kadoya, MD, PhD Yasumasa Tsuda, MD Takaomi Sekino, MD, PhD Norimichi Tashiro, MD, PhD Hirofumi Inoue, MD, PhD Yoshiko Nawata, MD Makoto Mizutani, MD, PhD Takashi Maki, MD Kenji Nakatsuka, MD, PhD Shunji Hasegawa, MD, PhD |
| author_sort | Fumiko Okazaki, MD |
| collection | DOAJ |
| description | Background: Non-immunoglobulin E-mediated gastrointestinal food allergies (non-IgE-GI-FAs) in children with Down syndrome (DS) tend to be more severe, with some children presenting with sepsis-like symptoms. However, the epidemiology of this condition remains unknown. This study aimed to investigate the prevalence rate and clinical characteristics of non-IgE-GI-FAs in children with DS. Methods: This study included 115 children with non-IgE-GI-FAs diagnosed at 13 hospitals in Yamaguchi Prefecture, Japan, between January 1, 2011, and December 31, 2020. The children were classified into DS and non-DS groups, and their clinical characteristics were retrospectively compared. Results: Among the 115 children with non-IgE-GI-FAs, 7 and 108 were included in the DS and non-DS groups, respectively. During the study period, 184 children with DS were born in Yamaguchi prefecture, and 7 developed non-IgE-GI-FAs. In this study, the prevalence rate of non-IgE-GI-FAs was 3.8% (7/184) in children with DS and 0.11% (108/98,989) in children without DS. No significant differences were observed in causative foods, age at onset, age at diagnosis, or age at confirmed clinical remission between the 2 groups. Most children in both groups experienced vomiting and diarrhea, but none had hypothermia. Sepsis-like symptoms, such as lethargy (71.4% vs. 24.1%, P = 0.0150), hypotension (42.9% vs. 0.9%, P = 0.0006), and fever (57.1% and 8.3%, P = 0.0030), were significantly more common in the DS group than in the non-DS group. Conclusions: The prevalence rate of non-IgE-GI-FAs was 3.8% in children with DS and 0.11% in children without DS. Non-IgE-GI-FAs in children with DS were significantly more severe than those in children without DS. Non-IgE-GI-FAs should be considered a differential diagnosis when sepsis-like symptoms are observed in children with DS. |
| format | Article |
| id | doaj-art-548c8c9538b94d96a68d6ceeafd5d298 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-548c8c9538b94d96a68d6ceeafd5d2982025-08-20T03:59:37ZengElsevierWorld Allergy Organization Journal1939-45512025-08-0118810110310.1016/j.waojou.2025.101103Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological studyFumiko Okazaki, MD0Hiroyuki Wakiguchi, MD, PhD1Yuno Korenaga, MD2Mototsugu Shimokawa, PhD3Tsuyoshi Tanabe, MD, PhD4Ken Fukuda, MD, PhD5Masanari Hasegawa, MD, PhD6Miho Shimizu, MD, PhD7Reiji Hirano, MD, PhD8Tadashi Moriwake, MD, PhD9Mai Kawamura, MD10Hiroshi Tateishi, MD, PhD11Ryo Kadoya, MD, PhD12Yasumasa Tsuda, MD13Takaomi Sekino, MD, PhD14Norimichi Tashiro, MD, PhD15Hirofumi Inoue, MD, PhD16Yoshiko Nawata, MD17Makoto Mizutani, MD, PhD18Takashi Maki, MD19Kenji Nakatsuka, MD, PhD20Shunji Hasegawa, MD, PhD21Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDepartment of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Corresponding author. , Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDepartment of Biostatistics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDepartment of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Division of Pediatrics, Shuto General Hospital, Yanai, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi Grand Medical Center, Hofu, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi Grand Medical Center, Hofu, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi-ken Saiseikai Shimonoseki General Hospital, Shimonoseki, Yamaguchi, JapanDivision of Pediatrics, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Yamaguchi, JapanDepartment of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Division of Pediatrics, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Yamaguchi, JapanDivision of Pediatrics, Japan Community Health Care Organization Tokuyama Central Hospital, Shunan, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi Red Cross Hospital, Yamaguchi, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi Red Cross Hospital, Yamaguchi, Yamaguchi, JapanDivision of Pediatrics, Ogori Daiichi General Hospital, Yamaguchi, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi Rosai Hospital, Sanyo-Onoda, Yamaguchi, JapanDivision of Pediatrics, Hagi Civil Hospital, Hagi, Yamaguchi, JapanDivision of Pediatrics, Hagi Civil Hospital, Hagi, Yamaguchi, JapanDivision of Pediatrics, Nagato General Hospital, Nagato, Yamaguchi, JapanDivision of Pediatrics, National Hospital Organization Kanmon Medical Center, Shimonoseki, Yamaguchi, JapanDivision of Pediatrics, Yamaguchi-ken Saiseikai Toyoura Hospital, Shimonoseki, Yamaguchi, JapanDepartment of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanBackground: Non-immunoglobulin E-mediated gastrointestinal food allergies (non-IgE-GI-FAs) in children with Down syndrome (DS) tend to be more severe, with some children presenting with sepsis-like symptoms. However, the epidemiology of this condition remains unknown. This study aimed to investigate the prevalence rate and clinical characteristics of non-IgE-GI-FAs in children with DS. Methods: This study included 115 children with non-IgE-GI-FAs diagnosed at 13 hospitals in Yamaguchi Prefecture, Japan, between January 1, 2011, and December 31, 2020. The children were classified into DS and non-DS groups, and their clinical characteristics were retrospectively compared. Results: Among the 115 children with non-IgE-GI-FAs, 7 and 108 were included in the DS and non-DS groups, respectively. During the study period, 184 children with DS were born in Yamaguchi prefecture, and 7 developed non-IgE-GI-FAs. In this study, the prevalence rate of non-IgE-GI-FAs was 3.8% (7/184) in children with DS and 0.11% (108/98,989) in children without DS. No significant differences were observed in causative foods, age at onset, age at diagnosis, or age at confirmed clinical remission between the 2 groups. Most children in both groups experienced vomiting and diarrhea, but none had hypothermia. Sepsis-like symptoms, such as lethargy (71.4% vs. 24.1%, P = 0.0150), hypotension (42.9% vs. 0.9%, P = 0.0006), and fever (57.1% and 8.3%, P = 0.0030), were significantly more common in the DS group than in the non-DS group. Conclusions: The prevalence rate of non-IgE-GI-FAs was 3.8% in children with DS and 0.11% in children without DS. Non-IgE-GI-FAs in children with DS were significantly more severe than those in children without DS. Non-IgE-GI-FAs should be considered a differential diagnosis when sepsis-like symptoms are observed in children with DS.http://www.sciencedirect.com/science/article/pii/S1939455125000808Down syndromeEpidemiologyFood allergyIgESepsis-like |
| spellingShingle | Fumiko Okazaki, MD Hiroyuki Wakiguchi, MD, PhD Yuno Korenaga, MD Mototsugu Shimokawa, PhD Tsuyoshi Tanabe, MD, PhD Ken Fukuda, MD, PhD Masanari Hasegawa, MD, PhD Miho Shimizu, MD, PhD Reiji Hirano, MD, PhD Tadashi Moriwake, MD, PhD Mai Kawamura, MD Hiroshi Tateishi, MD, PhD Ryo Kadoya, MD, PhD Yasumasa Tsuda, MD Takaomi Sekino, MD, PhD Norimichi Tashiro, MD, PhD Hirofumi Inoue, MD, PhD Yoshiko Nawata, MD Makoto Mizutani, MD, PhD Takashi Maki, MD Kenji Nakatsuka, MD, PhD Shunji Hasegawa, MD, PhD Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study World Allergy Organization Journal Down syndrome Epidemiology Food allergy IgE Sepsis-like |
| title | Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study |
| title_full | Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study |
| title_fullStr | Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study |
| title_full_unstemmed | Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study |
| title_short | Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study |
| title_sort | non immunoglobulin e mediated gastrointestinal food allergies in children with down syndrome an epidemiological study |
| topic | Down syndrome Epidemiology Food allergy IgE Sepsis-like |
| url | http://www.sciencedirect.com/science/article/pii/S1939455125000808 |
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