Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy
Abstract Background The standard treatment for Pregnancy-Associated Breast Cancer (PABC) includes surgery and neoadjuvant chemotherapy, which can impair fertility, emphasizing the critical need for fertility preservation in these patients. This case report discusses a breast cancer patient who was f...
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BMC
2025-02-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01615-4 |
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| author | Parisa Pirooznia Esmat Mashhadi Meighani Firouzeh Ghaffari |
| author_facet | Parisa Pirooznia Esmat Mashhadi Meighani Firouzeh Ghaffari |
| author_sort | Parisa Pirooznia |
| collection | DOAJ |
| description | Abstract Background The standard treatment for Pregnancy-Associated Breast Cancer (PABC) includes surgery and neoadjuvant chemotherapy, which can impair fertility, emphasizing the critical need for fertility preservation in these patients. This case report discusses a breast cancer patient who was found to be pregnant shortly after starting treatment. Despite the pregnancy and increased levels of βHCG and progesterone, the ovarian stimulation cycle yielded a satisfactory number of mature oocytes and high-quality embryos. Case presentation A 40-year-old woman, G1Ab1 (Gravida1Abortion1), who was diagnosed with Invasive Ductal Carcinoma with negative receptors (Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2) was referred to the oncofertility unit of the Royan Infertility Center for fertility preservation prior to the commencement of chemotherapy. Following necessary consultations and procedures, and confirming a negative pregnancy test, a random start letrozole-based protocol was initiated for ovarian stimulation. During the cycle, a positive pregnancy test was encountered. Despite the positive test, the cycle continued, and on day 13 of the cycle, triggering was performed with a GnRH agonist. A puncture was performed 36 h later, yielding 12 oocytes and 8 embryos. Conclusion This case highlights the feasibility of adapting random-start ovarian stimulation protocols during pregnancy, warranting further investigation in similar clinical scenarios. |
| format | Article |
| id | doaj-art-547ebd1e520446448237085d0f2e0176 |
| institution | DOAJ |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-547ebd1e520446448237085d0f2e01762025-08-20T03:03:22ZengBMCJournal of Ovarian Research1757-22152025-02-011811610.1186/s13048-025-01615-4Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancyParisa Pirooznia0Esmat Mashhadi Meighani1Firouzeh Ghaffari2Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECRAbstract Background The standard treatment for Pregnancy-Associated Breast Cancer (PABC) includes surgery and neoadjuvant chemotherapy, which can impair fertility, emphasizing the critical need for fertility preservation in these patients. This case report discusses a breast cancer patient who was found to be pregnant shortly after starting treatment. Despite the pregnancy and increased levels of βHCG and progesterone, the ovarian stimulation cycle yielded a satisfactory number of mature oocytes and high-quality embryos. Case presentation A 40-year-old woman, G1Ab1 (Gravida1Abortion1), who was diagnosed with Invasive Ductal Carcinoma with negative receptors (Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2) was referred to the oncofertility unit of the Royan Infertility Center for fertility preservation prior to the commencement of chemotherapy. Following necessary consultations and procedures, and confirming a negative pregnancy test, a random start letrozole-based protocol was initiated for ovarian stimulation. During the cycle, a positive pregnancy test was encountered. Despite the positive test, the cycle continued, and on day 13 of the cycle, triggering was performed with a GnRH agonist. A puncture was performed 36 h later, yielding 12 oocytes and 8 embryos. Conclusion This case highlights the feasibility of adapting random-start ovarian stimulation protocols during pregnancy, warranting further investigation in similar clinical scenarios.https://doi.org/10.1186/s13048-025-01615-4Pregnancy-associated breast cancerPABCFertility preservationRandom start ovarian stimulation |
| spellingShingle | Parisa Pirooznia Esmat Mashhadi Meighani Firouzeh Ghaffari Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy Journal of Ovarian Research Pregnancy-associated breast cancer PABC Fertility preservation Random start ovarian stimulation |
| title | Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy |
| title_full | Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy |
| title_fullStr | Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy |
| title_full_unstemmed | Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy |
| title_short | Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy |
| title_sort | exploring new frontiers in oncofertility preservation a case of ovarian stimulation during pregnancy |
| topic | Pregnancy-associated breast cancer PABC Fertility preservation Random start ovarian stimulation |
| url | https://doi.org/10.1186/s13048-025-01615-4 |
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