Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events
Background The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. Methods Using data from the UK Biobank, 39 363 participants underwent baseline cardiovascular magnetic resonance imaging and were categorized...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.040490 |
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| author | Yun‐Jiu Cheng Zi‐Li Liao Li‐Juan Liu Yue‐Dong Ma Xu‐Miao Chen Ze‐Xuan Wu Hui‐Qiang Wei Wei‐Dong Lin Yi‐Jian Liao Su‐Hua Wu Yu‐Mei Xue Li‐Chun Wang Yang Wu |
| author_facet | Yun‐Jiu Cheng Zi‐Li Liao Li‐Juan Liu Yue‐Dong Ma Xu‐Miao Chen Ze‐Xuan Wu Hui‐Qiang Wei Wei‐Dong Lin Yi‐Jian Liao Su‐Hua Wu Yu‐Mei Xue Li‐Chun Wang Yang Wu |
| author_sort | Yun‐Jiu Cheng |
| collection | DOAJ |
| description | Background The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. Methods Using data from the UK Biobank, 39 363 participants underwent baseline cardiovascular magnetic resonance imaging and were categorized into 3 groups based on left ventricular end‐diastolic volume index: small, normal, and large LV. Cox proportional hazards models were applied to evaluate the association between LV size and composite cardiovascular outcomes. Results An elevated prevalence of small LV was observed among the 4305 participants, with a notable trend toward increased occurrence in older individuals. Over a median follow‐up of 5.21 years, 1500 cases of major adverse cardiovascular events, 1096 coronary heart disease, 288 ischemic stroke, and 722 deaths from any cause occurred. After adjusting for multiple confounders, hazard ratios (HRs) of small LV comparing the normal LV were 1.24 (95% CI, 1.07–1.44) for major adverse cardiovascular events, 1.29 (95% CI, 1.09–1.53) for coronary heart disease, 1.53 (95% CI, 1.11–2.09) for ischemic stroke, and 1.33 (95% CI, 1.08–1.64) for death from all causes. Notably, a U‐shaped relationship was identified between left ventricular end‐diastolic volume index and cardiovascular outcomes. Subgroup analysis revealed that, compared with women, the presence of a small LV in men exhibited a significant correlation with adverse cardiovascular events, thereby demonstrating potential value in disease prediction and risk stratification. Conclusions These findings highlight the importance of considering small LV as a prognostic marker for cardiovascular disease and underscore the need for further research to elucidate the underlying mechanisms and develop targeted interventions. |
| format | Article |
| id | doaj-art-547ba3292ed24fcf83e04865a96eb4af |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-547ba3292ed24fcf83e04865a96eb4af2025-08-20T03:59:22ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-08-01141510.1161/JAHA.124.040490Association Between Size of Left Ventricle and Long‐Term Cardiovascular EventsYun‐Jiu Cheng0Zi‐Li Liao1Li‐Juan Liu2Yue‐Dong Ma3Xu‐Miao Chen4Ze‐Xuan Wu5Hui‐Qiang Wei6Wei‐Dong Lin7Yi‐Jian Liao8Su‐Hua Wu9Yu‐Mei Xue10Li‐Chun Wang11Yang Wu12Department of Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou ChinaDepartment of Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaDepartment of Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou ChinaDepartment of Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou ChinaThe First Clinical Medical College, Guangdong Medical University Zhanjiang ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaGuangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou Guangdong ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaDepartment of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou ChinaBackground The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. Methods Using data from the UK Biobank, 39 363 participants underwent baseline cardiovascular magnetic resonance imaging and were categorized into 3 groups based on left ventricular end‐diastolic volume index: small, normal, and large LV. Cox proportional hazards models were applied to evaluate the association between LV size and composite cardiovascular outcomes. Results An elevated prevalence of small LV was observed among the 4305 participants, with a notable trend toward increased occurrence in older individuals. Over a median follow‐up of 5.21 years, 1500 cases of major adverse cardiovascular events, 1096 coronary heart disease, 288 ischemic stroke, and 722 deaths from any cause occurred. After adjusting for multiple confounders, hazard ratios (HRs) of small LV comparing the normal LV were 1.24 (95% CI, 1.07–1.44) for major adverse cardiovascular events, 1.29 (95% CI, 1.09–1.53) for coronary heart disease, 1.53 (95% CI, 1.11–2.09) for ischemic stroke, and 1.33 (95% CI, 1.08–1.64) for death from all causes. Notably, a U‐shaped relationship was identified between left ventricular end‐diastolic volume index and cardiovascular outcomes. Subgroup analysis revealed that, compared with women, the presence of a small LV in men exhibited a significant correlation with adverse cardiovascular events, thereby demonstrating potential value in disease prediction and risk stratification. Conclusions These findings highlight the importance of considering small LV as a prognostic marker for cardiovascular disease and underscore the need for further research to elucidate the underlying mechanisms and develop targeted interventions.https://www.ahajournals.org/doi/10.1161/JAHA.124.040490cardiac magnetic resonance imagingcardiovascular diseaseleft ventricular end‐diastolic volume indexsmall left ventricle |
| spellingShingle | Yun‐Jiu Cheng Zi‐Li Liao Li‐Juan Liu Yue‐Dong Ma Xu‐Miao Chen Ze‐Xuan Wu Hui‐Qiang Wei Wei‐Dong Lin Yi‐Jian Liao Su‐Hua Wu Yu‐Mei Xue Li‐Chun Wang Yang Wu Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiac magnetic resonance imaging cardiovascular disease left ventricular end‐diastolic volume index small left ventricle |
| title | Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events |
| title_full | Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events |
| title_fullStr | Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events |
| title_full_unstemmed | Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events |
| title_short | Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events |
| title_sort | association between size of left ventricle and long term cardiovascular events |
| topic | cardiac magnetic resonance imaging cardiovascular disease left ventricular end‐diastolic volume index small left ventricle |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.040490 |
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