BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancy

BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancy

Abstract Background Placental angiogenesis is particularly important in the treatment of intrahepatic cholestasis of pregnancy (ICP). Although BACH1 has been implicated in angiogenesis associated with cardiovascular diseases, its specific role and underlying mechanisms in ICP remain unclear. This st...

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Bibliographic Details
Main Authors: Shengpeng Li, Weiying Zhu, Zhixuan Xing, Dan Chen, Huimin Zhao, Yanli Zhang, Wenlong Zhang, Jiaojiao Sun, Yaxian Wu, Ling Ai, Qingfeng Pang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
BACH1
SLC25A51
NAD+
Angiogenesis
Intrahepatic cholestasis of pregnancy
Online Access:https://doi.org/10.1186/s10020-025-01215-4
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