Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance
Abstract This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by antimicrobial resistance, it is crucial to first und...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-11-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400068 |
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| _version_ | 1846169191114080256 |
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| author | Nafise Elahpour Isabella Niesner Nora Abdellaoui Boris Michael Holzapfel Lukas Gritsch Edouard Jallot Susanne Mayer‐Wagner Jonathan Lao |
| author_facet | Nafise Elahpour Isabella Niesner Nora Abdellaoui Boris Michael Holzapfel Lukas Gritsch Edouard Jallot Susanne Mayer‐Wagner Jonathan Lao |
| author_sort | Nafise Elahpour |
| collection | DOAJ |
| description | Abstract This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by antimicrobial resistance, it is crucial to first understand the mechanisms of pathogenesis, persistence, and bacterial resistance in skeletal infection, and then develop effective counterstrategies and innovative alternatives. This review considers the role of antimicrobial metal ions, their mechanism of action, and their incorporation into bioactive glass formulations as these materials can serve as delivery platforms with the least possible complexities. Furthermore, the bacterial infection risk in bone is also examined with specific attention to antibiotic resistance and biofilm formation. This review sheds light on the most promising materials as novel antibacterial agents by presenting a wide range of possible bioactive glass formulations equipped with potential antibacterial ions and in vitro/ in vivo insights, and it also reinforces the importance of continuing studies to develop multi‐faceted antibacterial bioactive glasses. |
| format | Article |
| id | doaj-art-54777ac0608e4fa694a4d26af96dc4b0 |
| institution | Kabale University |
| issn | 2196-7350 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-54777ac0608e4fa694a4d26af96dc4b02024-11-13T05:43:49ZengWiley-VCHAdvanced Materials Interfaces2196-73502024-11-011132n/an/a10.1002/admi.202400068Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic ResistanceNafise Elahpour0Isabella Niesner1Nora Abdellaoui2Boris Michael Holzapfel3Lukas Gritsch4Edouard Jallot5Susanne Mayer‐Wagner6Jonathan Lao7Laboratoire de Physique de Clermont (LPC) Université Clermont Auvergne CNRS/IN2P3 Clermont‐Ferrand F‐63000 FranceDepartment of Orthopaedics and Trauma Surgery Musculoskeletal University Center Munich (MUM) LMU University Hospital LMU Munich 80336 Munich GermanyLaboratoire de Physique de Clermont (LPC) Université Clermont Auvergne CNRS/IN2P3 Clermont‐Ferrand F‐63000 FranceDepartment of Orthopaedics and Trauma Surgery Musculoskeletal University Center Munich (MUM) LMU University Hospital LMU Munich 80336 Munich GermanyLaboratoire de Physique de Clermont (LPC) Université Clermont Auvergne CNRS/IN2P3 Clermont‐Ferrand F‐63000 FranceLaboratoire de Physique de Clermont (LPC) Université Clermont Auvergne CNRS/IN2P3 Clermont‐Ferrand F‐63000 FranceDepartment of Orthopaedics and Trauma Surgery Musculoskeletal University Center Munich (MUM) LMU University Hospital LMU Munich 80336 Munich GermanyLaboratoire de Physique de Clermont (LPC) Université Clermont Auvergne CNRS/IN2P3 Clermont‐Ferrand F‐63000 FranceAbstract This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by antimicrobial resistance, it is crucial to first understand the mechanisms of pathogenesis, persistence, and bacterial resistance in skeletal infection, and then develop effective counterstrategies and innovative alternatives. This review considers the role of antimicrobial metal ions, their mechanism of action, and their incorporation into bioactive glass formulations as these materials can serve as delivery platforms with the least possible complexities. Furthermore, the bacterial infection risk in bone is also examined with specific attention to antibiotic resistance and biofilm formation. This review sheds light on the most promising materials as novel antibacterial agents by presenting a wide range of possible bioactive glass formulations equipped with potential antibacterial ions and in vitro/ in vivo insights, and it also reinforces the importance of continuing studies to develop multi‐faceted antibacterial bioactive glasses.https://doi.org/10.1002/admi.202400068antibacterial treatmentbioactive glassbiomaterial associated infectionion doping |
| spellingShingle | Nafise Elahpour Isabella Niesner Nora Abdellaoui Boris Michael Holzapfel Lukas Gritsch Edouard Jallot Susanne Mayer‐Wagner Jonathan Lao Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance Advanced Materials Interfaces antibacterial treatment bioactive glass biomaterial associated infection ion doping |
| title | Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance |
| title_full | Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance |
| title_fullStr | Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance |
| title_full_unstemmed | Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance |
| title_short | Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance |
| title_sort | antibacterial therapeutic ions incorporation into bioactive glasses as a winning strategy against antibiotic resistance |
| topic | antibacterial treatment bioactive glass biomaterial associated infection ion doping |
| url | https://doi.org/10.1002/admi.202400068 |
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