Wound Healing Splinting Devices for Faster Access and Use
With the goal of studying skin wound healing and testing new drug treatments to enhance wound healing in rodent models, there is a clear need for improved splinting techniques to increase surgical efficiency and support routine wound monitoring. Splinted wound healing models humanize wound healing i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | JID Innovations |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026724000808 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850035218844483584 |
|---|---|
| author | Andrew W. Miller Alexa R. Anderson Alejandra Suarez-Arnedo Tatiana Segura |
| author_facet | Andrew W. Miller Alexa R. Anderson Alejandra Suarez-Arnedo Tatiana Segura |
| author_sort | Andrew W. Miller |
| collection | DOAJ |
| description | With the goal of studying skin wound healing and testing new drug treatments to enhance wound healing in rodent models, there is a clear need for improved splinting techniques to increase surgical efficiency and support routine wound monitoring. Splinted wound healing models humanize wound healing in rodents to prevent contraction and instead heal through granulation tissue deposition, increasing the relevance to human wound healing. Current technologies require suturing and heavy wrapping, leading to splint failure and cumbersome monitoring of the wound. In this study, we developed a splint with resealable cap system that provides ease of access for wound inspection, therapeutic treatment delivery, and routine wound imaging without the need to unwrap and wrap the animal. Meanwhile, to overcome the challenges associated with suturing, we also developed adherent splints that can be applied to both hairless or haired mice with minimal wrapping. Both technologies are expected to improve and encourage the adoption of splinted wound healing models. |
| format | Article |
| id | doaj-art-54773e174b78482b97da23b7aee7db05 |
| institution | DOAJ |
| issn | 2667-0267 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj-art-54773e174b78482b97da23b7aee7db052025-08-20T02:57:33ZengElsevierJID Innovations2667-02672025-03-015210033210.1016/j.xjidi.2024.100332Wound Healing Splinting Devices for Faster Access and UseAndrew W. Miller0Alexa R. Anderson1Alejandra Suarez-Arnedo2Tatiana Segura3Department of Biomedical Engineering, Duke University, Durham, North Carolina, USADepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USADepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USADepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA; Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA; Department of Dermatology, Duke University School of Medicine, Durham, North Carolina, USA; Correspondence: Tatiana Segura, Department of Biomedical Engineering, Duke University, 534 Research Drive, Wilkinson Building Rm 313, Durham, North Carolina 27708-0281, USA.With the goal of studying skin wound healing and testing new drug treatments to enhance wound healing in rodent models, there is a clear need for improved splinting techniques to increase surgical efficiency and support routine wound monitoring. Splinted wound healing models humanize wound healing in rodents to prevent contraction and instead heal through granulation tissue deposition, increasing the relevance to human wound healing. Current technologies require suturing and heavy wrapping, leading to splint failure and cumbersome monitoring of the wound. In this study, we developed a splint with resealable cap system that provides ease of access for wound inspection, therapeutic treatment delivery, and routine wound imaging without the need to unwrap and wrap the animal. Meanwhile, to overcome the challenges associated with suturing, we also developed adherent splints that can be applied to both hairless or haired mice with minimal wrapping. Both technologies are expected to improve and encourage the adoption of splinted wound healing models.http://www.sciencedirect.com/science/article/pii/S2667026724000808ImagingMethodsModelsTechniquesTools |
| spellingShingle | Andrew W. Miller Alexa R. Anderson Alejandra Suarez-Arnedo Tatiana Segura Wound Healing Splinting Devices for Faster Access and Use JID Innovations Imaging Methods Models Techniques Tools |
| title | Wound Healing Splinting Devices for Faster Access and Use |
| title_full | Wound Healing Splinting Devices for Faster Access and Use |
| title_fullStr | Wound Healing Splinting Devices for Faster Access and Use |
| title_full_unstemmed | Wound Healing Splinting Devices for Faster Access and Use |
| title_short | Wound Healing Splinting Devices for Faster Access and Use |
| title_sort | wound healing splinting devices for faster access and use |
| topic | Imaging Methods Models Techniques Tools |
| url | http://www.sciencedirect.com/science/article/pii/S2667026724000808 |
| work_keys_str_mv | AT andrewwmiller woundhealingsplintingdevicesforfasteraccessanduse AT alexaranderson woundhealingsplintingdevicesforfasteraccessanduse AT alejandrasuarezarnedo woundhealingsplintingdevicesforfasteraccessanduse AT tatianasegura woundhealingsplintingdevicesforfasteraccessanduse |