Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11.

Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11.

Recombinant antibodies are of profound clinical significance; yet, anti-carbohydrate antibodies are prone to undesirable cross-reactivity with structurally related-glycans. Here we introduce a new technology called Computational Carbohydrate Grafting (CCG), which enables a virtual library of glycans...

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Bibliographic Details
Main Authors: Matthew B Tessier, Oliver C Grant, Jamie Heimburg-Molinaro, David Smith, Snehal Jadey, Andrew M Gulick, John Glushka, Susan L Deutscher, Kate Rittenhouse-Olson, Robert J Woods
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0054874
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https://doi.org/10.1371/journal.pone.0054874

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