Invariant natural killer T cells minimally influence gut microbiota composition in mice
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic molecules within only minutes of activation....
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2104087 |
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| author | Qiaochu Lin Meggie Kuypers Zhewei Liu Julia K Copeland Donny Chan Susan J Robertson Jean Kontogiannis David S Guttman E. Kate Banks Dana J Philpott Thierry Mallevaey |
| author_facet | Qiaochu Lin Meggie Kuypers Zhewei Liu Julia K Copeland Donny Chan Susan J Robertson Jean Kontogiannis David S Guttman E. Kate Banks Dana J Philpott Thierry Mallevaey |
| author_sort | Qiaochu Lin |
| collection | DOAJ |
| description | Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic molecules within only minutes of activation. As such, iNKT cells can fuel or dampen inflammation in a context-dependent manner. In addition, iNKT cells provide potent immunity against bacteria, viruses, parasites and fungi. Although microbiota-iNKT cell interactions are not well-characterized, mounting evidence suggests that microbiota colonization early in life impacts iNKT cell homeostasis and functions in disease. In this study, we showed that CD1d−/− and Vα14 Tg mice, which lack and have increased numbers of iNKT cells, respectively, had no significant alterations in gut microbiota composition compared to their littermate controls. Furthermore, specific iNKT cell activation by glycolipid antigens only resulted in a transient and minimal shift in microbiota composition when compared to the natural drift found in our colony. Our findings demonstrate that iNKT cells have little to no influence in regulating commensal bacteria at steady state.Abbreviations: iNKT: invariant Natural Killer T cell; αGC: α-galactosylceramide |
| format | Article |
| id | doaj-art-545f76b4b1774dba9ea0db17924006eb |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-545f76b4b1774dba9ea0db17924006eb2025-08-20T03:05:25ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2104087Invariant natural killer T cells minimally influence gut microbiota composition in miceQiaochu Lin0Meggie Kuypers1Zhewei Liu2Julia K Copeland3Donny Chan4Susan J Robertson5Jean Kontogiannis6David S Guttman7E. Kate Banks8Dana J Philpott9Thierry Mallevaey10Department of Immunology, University of Toronto, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, CanadaCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaDivision of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, CanadaDivision of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaInvariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic molecules within only minutes of activation. As such, iNKT cells can fuel or dampen inflammation in a context-dependent manner. In addition, iNKT cells provide potent immunity against bacteria, viruses, parasites and fungi. Although microbiota-iNKT cell interactions are not well-characterized, mounting evidence suggests that microbiota colonization early in life impacts iNKT cell homeostasis and functions in disease. In this study, we showed that CD1d−/− and Vα14 Tg mice, which lack and have increased numbers of iNKT cells, respectively, had no significant alterations in gut microbiota composition compared to their littermate controls. Furthermore, specific iNKT cell activation by glycolipid antigens only resulted in a transient and minimal shift in microbiota composition when compared to the natural drift found in our colony. Our findings demonstrate that iNKT cells have little to no influence in regulating commensal bacteria at steady state.Abbreviations: iNKT: invariant Natural Killer T cell; αGC: α-galactosylceramidehttps://www.tandfonline.com/doi/10.1080/19490976.2022.2104087iNKT cellsCD1dα-galactosylceramidemicrobiotacross-fostering |
| spellingShingle | Qiaochu Lin Meggie Kuypers Zhewei Liu Julia K Copeland Donny Chan Susan J Robertson Jean Kontogiannis David S Guttman E. Kate Banks Dana J Philpott Thierry Mallevaey Invariant natural killer T cells minimally influence gut microbiota composition in mice Gut Microbes iNKT cells CD1d α-galactosylceramide microbiota cross-fostering |
| title | Invariant natural killer T cells minimally influence gut microbiota composition in mice |
| title_full | Invariant natural killer T cells minimally influence gut microbiota composition in mice |
| title_fullStr | Invariant natural killer T cells minimally influence gut microbiota composition in mice |
| title_full_unstemmed | Invariant natural killer T cells minimally influence gut microbiota composition in mice |
| title_short | Invariant natural killer T cells minimally influence gut microbiota composition in mice |
| title_sort | invariant natural killer t cells minimally influence gut microbiota composition in mice |
| topic | iNKT cells CD1d α-galactosylceramide microbiota cross-fostering |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2104087 |
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