lncRNA RP11-34D15.2 sponges miR-223 to promote the PGC-1α/irisin signaling pathway, contributing to increased FFA and insulin resistance in obese children

lncRNA RP11-34D15.2 sponges miR-223 to promote the PGC-1α/irisin signaling pathway, contributing to increased FFA and insulin resistance in obese children

Background: The global surge in pediatric obesity is closely linked to insulin resistance (IR) and type 2 diabetes, where adipose tissue free fatty acid (FFA) overload and mitochondrial dysfunction play pivotal roles. Long non-coding RNAs (lncRNAs) are emerging regulators of metabolic diseases, but...

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Bibliographic Details
Main Authors: Shuang Guo, Mengnan Lu, Yuesheng Liu, Hongai Zhang, Biyao Lian, Yanfeng Xiao, Chunyan Yin
Format: Article
Language:English
Published: Bioscientifica 2025-06-01
Series:Endocrine Connections
Subjects:
insulin resistance
lncrna rp11-34d15.2
mir-223
free fatty acids
pediatric obesity
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0028.xml
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