Contemporary Tailored Oncology Treatment of Biliary Tract Cancers
Biliary tract cancers (BTCs) are poor prognosis malignancies with limited treatment options. Capecitabine has recently emerged as an effective agent in the adjuvant setting; however, treatment of advanced disease is still limited to first-line cisplatin and gemcitabine chemotherapy. Recent global ef...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7698786 |
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| author | Fiona Turkes Juliet Carmichael David Cunningham Naureen Starling |
| author_facet | Fiona Turkes Juliet Carmichael David Cunningham Naureen Starling |
| author_sort | Fiona Turkes |
| collection | DOAJ |
| description | Biliary tract cancers (BTCs) are poor prognosis malignancies with limited treatment options. Capecitabine has recently emerged as an effective agent in the adjuvant setting; however, treatment of advanced disease is still limited to first-line cisplatin and gemcitabine chemotherapy. Recent global efforts in genomic profiling and molecular subtyping of BTCs have uncovered a wealth of genomic aberrations which may carry prognostic significance and/or predict response to treatment, and several targeted agents have shown promising results in clinical trials. As such, the uptake of comprehensive genomic profiling for patients with BTCs and the expansion of basket trials to include these patients are growing. This review describes the currently approved systemic therapies for BTCs and provides insight into the emerging targeted and immunotherapeutic agents, as well as conventional chemotherapeutic regimes, currently being investigated in clinical trials. |
| format | Article |
| id | doaj-art-54542fcdbd0540e68ecb02a12d17c130 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-54542fcdbd0540e68ecb02a12d17c1302025-08-20T02:05:46ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/76987867698786Contemporary Tailored Oncology Treatment of Biliary Tract CancersFiona Turkes0Juliet Carmichael1David Cunningham2Naureen Starling3Department of Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UKDepartment of Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UKDepartment of Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UKDepartment of Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UKBiliary tract cancers (BTCs) are poor prognosis malignancies with limited treatment options. Capecitabine has recently emerged as an effective agent in the adjuvant setting; however, treatment of advanced disease is still limited to first-line cisplatin and gemcitabine chemotherapy. Recent global efforts in genomic profiling and molecular subtyping of BTCs have uncovered a wealth of genomic aberrations which may carry prognostic significance and/or predict response to treatment, and several targeted agents have shown promising results in clinical trials. As such, the uptake of comprehensive genomic profiling for patients with BTCs and the expansion of basket trials to include these patients are growing. This review describes the currently approved systemic therapies for BTCs and provides insight into the emerging targeted and immunotherapeutic agents, as well as conventional chemotherapeutic regimes, currently being investigated in clinical trials.http://dx.doi.org/10.1155/2019/7698786 |
| spellingShingle | Fiona Turkes Juliet Carmichael David Cunningham Naureen Starling Contemporary Tailored Oncology Treatment of Biliary Tract Cancers Gastroenterology Research and Practice |
| title | Contemporary Tailored Oncology Treatment of Biliary Tract Cancers |
| title_full | Contemporary Tailored Oncology Treatment of Biliary Tract Cancers |
| title_fullStr | Contemporary Tailored Oncology Treatment of Biliary Tract Cancers |
| title_full_unstemmed | Contemporary Tailored Oncology Treatment of Biliary Tract Cancers |
| title_short | Contemporary Tailored Oncology Treatment of Biliary Tract Cancers |
| title_sort | contemporary tailored oncology treatment of biliary tract cancers |
| url | http://dx.doi.org/10.1155/2019/7698786 |
| work_keys_str_mv | AT fionaturkes contemporarytailoredoncologytreatmentofbiliarytractcancers AT julietcarmichael contemporarytailoredoncologytreatmentofbiliarytractcancers AT davidcunningham contemporarytailoredoncologytreatmentofbiliarytractcancers AT naureenstarling contemporarytailoredoncologytreatmentofbiliarytractcancers |