Pulsatilla saponin inhibits the proliferation of keratinocytes and ameliorates imiquimod-induced psoriasis through the NF-κB and STAT3 signaling pathways

Pulsatilla saponin inhibits the proliferation of keratinocytes and ameliorates imiquimod-induced psoriasis through the NF-κB and STAT3 signaling pathways

Background and aim: Pulsatilla saponin (Ps) was isolated from Pulsatilla chinensis (Bunge) Regel, a traditional Chinese medicine, that has anti-proliferation, anti-inflammation, anti-tumor and immunomodulation activities. However, the anti-psoriasis activity of Ps and its underlying mechanisms have...

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Bibliographic Details
Main Authors: Jilang Li, Haixin Qiu, Siyuan Li, Shan Han, Yuming He, Jia He, Xiang Gao, Jingjing Li, Jianfang Feng, Shilin Yang, Renyikun Yuan, Hongwei Gao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
Pulsatilla saponin
STAT3
NF-κB
Psoriasis
Th17
Inflammation cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411024000373
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