Gender-related differences in manifestations, complications, and mortality rate of systolic heart failure patients
Background & Aims: Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Important differences in comorbidities and clinical characteristics exist between women and men with heart failure. This study aimed to explore the influence of gender on the clinical manifestation...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Urmia University of Medical Sciences
2025-04-01
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| Series: | Health Science Monitor |
| Subjects: | |
| Online Access: | http://hsm.umsu.ac.ir/article-1-203-en.pdf |
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| Summary: | Background & Aims: Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Important differences in comorbidities and clinical characteristics exist between women and men with heart failure. This study aimed to explore the influence of gender on the clinical manifestations, complications, and mortality of patients with systolic heart failure.
Materials & Methods: In this cross-sectional study, medical records of all patients who were hospitalized with heart failure between September 2020 and September 2022 were examined. The study gathered information on demographic characteristics, coronary risk factors, clinical symptoms, pathological features, use of selected drugs, and other comorbidities.
Results: Of 1340 patients, 67.2% were men and 32.8% were women with a mean age of 70.58 ± 14.34 years. Fifty-seven (4.2%) patients had the first New York Heart Association (NYHA) class, 120 (8.9%) had the second, 341 (25.5%) had the third, and 161 (12.01%) patients had the fourth NYHA class. The mortality rate and mean ejection fraction (EF) were high in women (9.73%, 35 ± 13.27, respectively). The men had a higher glomerular filtration rate (GFR) (50.45 ± 15.43) than women (40.68 ± 13.98), which was significant (p = 0.01). The history of hypertension and myocardial infarction (MI) was high in men (86.36% and 33%, respectively) which were significant (p = 0.02, p = 0.005, respectively). No gender differences were found in laboratory findings (p ˂ 0.05). The consumption of drugs was more common in women than in men; therefore, it was not statistically significant (p < 0.05).
Conclusion: This study revealed that women have a significantly higher mean age and EF, drug consumption, and hospital mortality rate compared to men. Otherwise, men have a significantly higher history of hypertension, NYHU function class, and ischemic heart disease. |
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| ISSN: | 2980-8723 |