The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series
Omalizumab, a monoclonal anti-IgE antibody, has been used off-label in a few case series of bullous pemphigoids (BPs) with rapid efficacy and high safety profile. However, there is a lack of data to select patients who would get the most therapeutic benefit from omalizumab therapy. To assess if eosi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Dermatology |
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| Online Access: | https://journals.lww.com/10.4103/ijd.ijd_236_23 |
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| author | Gülfem Akin Ceylan Avci Sevgi Akarsu |
| author_facet | Gülfem Akin Ceylan Avci Sevgi Akarsu |
| author_sort | Gülfem Akin |
| collection | DOAJ |
| description | Omalizumab, a monoclonal anti-IgE antibody, has been used off-label in a few case series of bullous pemphigoids (BPs) with rapid efficacy and high safety profile. However, there is a lack of data to select patients who would get the most therapeutic benefit from omalizumab therapy. To assess if eosinophil-to-lymphocyte ratio (ELR), total serum IgE level, and serum eosinophil percentage would be useful in predicting response to omalizumab therapy in patients with BP. Medical records of 10 patients with BP treated with omalizumab were retrospectively analysed for clinical and laboratory data. ELRs, total serum IgE levels, and serum eosinophil percentages were compared between groups of complete responders and partial responders/flare-ups, but the results were not statistically significant. Studies with larger sample sizes should be done to predict the role of type 2 immunity markers in omalizumab therapy of BP patients. |
| format | Article |
| id | doaj-art-544599cc24754a42b9f427d1eae5baed |
| institution | Kabale University |
| issn | 0019-5154 1998-3611 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj-art-544599cc24754a42b9f427d1eae5baed2025-01-20T10:33:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112024-01-01691818510.4103/ijd.ijd_236_23The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case SeriesGülfem AkinCeylan AvciSevgi AkarsuOmalizumab, a monoclonal anti-IgE antibody, has been used off-label in a few case series of bullous pemphigoids (BPs) with rapid efficacy and high safety profile. However, there is a lack of data to select patients who would get the most therapeutic benefit from omalizumab therapy. To assess if eosinophil-to-lymphocyte ratio (ELR), total serum IgE level, and serum eosinophil percentage would be useful in predicting response to omalizumab therapy in patients with BP. Medical records of 10 patients with BP treated with omalizumab were retrospectively analysed for clinical and laboratory data. ELRs, total serum IgE levels, and serum eosinophil percentages were compared between groups of complete responders and partial responders/flare-ups, but the results were not statistically significant. Studies with larger sample sizes should be done to predict the role of type 2 immunity markers in omalizumab therapy of BP patients.https://journals.lww.com/10.4103/ijd.ijd_236_23bullous pemphigoideosinophillymphocyteomalizumabtype 2 immunity |
| spellingShingle | Gülfem Akin Ceylan Avci Sevgi Akarsu The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series Indian Journal of Dermatology bullous pemphigoid eosinophil lymphocyte omalizumab type 2 immunity |
| title | The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series |
| title_full | The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series |
| title_fullStr | The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series |
| title_full_unstemmed | The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series |
| title_short | The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series |
| title_sort | significance of eosinophil to lymphocyte ratio in predicting response to omalizumab treatment in patients with bullous pemphigoid a case series |
| topic | bullous pemphigoid eosinophil lymphocyte omalizumab type 2 immunity |
| url | https://journals.lww.com/10.4103/ijd.ijd_236_23 |
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