Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology
The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advance...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572821/full |
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| author | Shuang Ma Ying Lu Shang Sui Jia-shuo Yang Bing-bing Fu Pei-xin Tan Yicheng Chai Jiaqi Lv Lingyu Kong Xiaolin Wu Yi-bo Gao Tao Yan |
| author_facet | Shuang Ma Ying Lu Shang Sui Jia-shuo Yang Bing-bing Fu Pei-xin Tan Yicheng Chai Jiaqi Lv Lingyu Kong Xiaolin Wu Yi-bo Gao Tao Yan |
| author_sort | Shuang Ma |
| collection | DOAJ |
| description | The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. Furthermore, it elucidates the mechanisms, applications, and limitations of various immunotherapy modalities, including immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, and combined chemoimmunotherapy, while examining their effects on skeletal muscle function and systemic immune responses. Key findings indicate that although immunotherapy is effective in augmenting antitumor immunity, it frequently induces muscle-related adverse effects such as weakness, fatigue, or damage, primarily mediated by cytokine release and immune activation. This work underscores the significance of immune niches within the tumor microenvironment in influencing treatment outcomes and proposes strategies to optimize therapy through personalized regimens and combinatorial approaches. This review highlights the need for further research on the formation of immune niches and interactions muscle-tumor. Our work is crucial for advancing the efficacy of immunotherapy, reducing adverse effects, and ultimately improving survival rates and quality of life of patients with cancer. |
| format | Article |
| id | doaj-art-54457f6b4fd84c1e8d255497329b9eec |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-54457f6b4fd84c1e8d255497329b9eec2025-08-20T01:51:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15728211572821Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncologyShuang Ma0Ying Lu1Shang Sui2Jia-shuo Yang3Bing-bing Fu4Pei-xin Tan5Yicheng Chai6Jiaqi Lv7Lingyu Kong8Xiaolin Wu9Yi-bo Gao10Tao Yan11School of Information Science and Engineering, Shenyang Ligong University, Shenyang, ChinaSchool of Information Science and Engineering, Shenyang Ligong University, Shenyang, ChinaSt. John’s Kilmarnock School, Breslau, ON, CanadaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSchool of Information Science and Engineering, Shenyang Ligong University, Shenyang, ChinaSchool of Information Science and Engineering, Shenyang Ligong University, Shenyang, ChinaSchool of Information Science and Engineering, Shenyang Ligong University, Shenyang, ChinaSchool of Mathematics and Statistics, Liaoning University, Shenyang, ChinaDepartment of Oral and Maxillofacial Surgery, Taikang Bybo Dental, Beijing, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaThe intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. Furthermore, it elucidates the mechanisms, applications, and limitations of various immunotherapy modalities, including immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, and combined chemoimmunotherapy, while examining their effects on skeletal muscle function and systemic immune responses. Key findings indicate that although immunotherapy is effective in augmenting antitumor immunity, it frequently induces muscle-related adverse effects such as weakness, fatigue, or damage, primarily mediated by cytokine release and immune activation. This work underscores the significance of immune niches within the tumor microenvironment in influencing treatment outcomes and proposes strategies to optimize therapy through personalized regimens and combinatorial approaches. This review highlights the need for further research on the formation of immune niches and interactions muscle-tumor. Our work is crucial for advancing the efficacy of immunotherapy, reducing adverse effects, and ultimately improving survival rates and quality of life of patients with cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572821/fulltumor microenvironmentimmunotherapyimmune checkpoint inhibitorsimmune nichesskeletal muscle biomechanics |
| spellingShingle | Shuang Ma Ying Lu Shang Sui Jia-shuo Yang Bing-bing Fu Pei-xin Tan Yicheng Chai Jiaqi Lv Lingyu Kong Xiaolin Wu Yi-bo Gao Tao Yan Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology Frontiers in Immunology tumor microenvironment immunotherapy immune checkpoint inhibitors immune niches skeletal muscle biomechanics |
| title | Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology |
| title_full | Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology |
| title_fullStr | Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology |
| title_full_unstemmed | Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology |
| title_short | Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology |
| title_sort | unraveling the triad of immunotherapy tumor microenvironment and skeletal muscle biomechanics in oncology |
| topic | tumor microenvironment immunotherapy immune checkpoint inhibitors immune niches skeletal muscle biomechanics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572821/full |
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