Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity
Abstract This retrospective study included 52 euthyroid women (with TAI, n = 26; without TAI, n = 26) undergoing ART. Based on E2 levels on the day of final oocyte maturation (DFOM) they were subdivided into Group A1 (TAI, E2 < 7,000 pmol/l), Group A2 (TAI, E2 > 7,000 pmol/l), Group B1 (no TAI...
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2025-07-01
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| author | Sanja Medenica Durairaj Arjunan Eliana Garalejic Pinaki Dutta Milos Zarkovic |
| author_facet | Sanja Medenica Durairaj Arjunan Eliana Garalejic Pinaki Dutta Milos Zarkovic |
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| description | Abstract This retrospective study included 52 euthyroid women (with TAI, n = 26; without TAI, n = 26) undergoing ART. Based on E2 levels on the day of final oocyte maturation (DFOM) they were subdivided into Group A1 (TAI, E2 < 7,000 pmol/l), Group A2 (TAI, E2 > 7,000 pmol/l), Group B1 (no TAI, E2 < 7,000 pmol/l), and Group B2 (no TAI, E2 > 7,000 pmol/l), to compare outcomes related to oocytes, embryos, and pregnancy. Group A2 had significantly more retrieved oocytes than A1, but no difference in good-quality oocytes, retrieved embryos, top-quality embryos, or pregnancy outcomes. Group B2 had a significantly higher number of retrieved oocytes [11 (8.25, 15.5) vs. 6.50 (3.75, 8.25), p = 0.001], good-quality oocytes [8.5 (6.25, 10.5) vs. 5 (1.75, 6), p = 0.001], retrieved embryos [5 (4, 8.5) vs. 3.75 (1.75, 4.25), p = 0.011] and top-quality embryos [4.5 (3, 6) vs. 3 (1, 4), p = 0.023], compared to Group B1, respectively. The positive correlation between high E2 levels and ART outcomes persisted after adjusting for potential confounders. Higher E2 levels on DFOM are linked to better oocyte and embryo outcomes, especially in patients without TAI, but don’t correlate with improved pregnancy outcomes. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-5444ab5f07db496ba20fae46bc6efc472025-08-20T03:38:12ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-04991-5Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunitySanja Medenica0Durairaj Arjunan1Eliana Garalejic2Pinaki Dutta3Milos Zarkovic4Department of Endocrinology, Internal Medicine Clinic, School of Medicine, Clinical Center of Montenegro, University of MontenegroDepartment of Endocrinology, Post Graduate Institute of Medical Education and ResearchIn Vitro Fertilisation Department, Clinic for Gynecology and Obstetrics “Narodni front”Department of Endocrinology, Post Graduate Institute of Medical Education and ResearchSchool of Medicine, University of BelgradeAbstract This retrospective study included 52 euthyroid women (with TAI, n = 26; without TAI, n = 26) undergoing ART. Based on E2 levels on the day of final oocyte maturation (DFOM) they were subdivided into Group A1 (TAI, E2 < 7,000 pmol/l), Group A2 (TAI, E2 > 7,000 pmol/l), Group B1 (no TAI, E2 < 7,000 pmol/l), and Group B2 (no TAI, E2 > 7,000 pmol/l), to compare outcomes related to oocytes, embryos, and pregnancy. Group A2 had significantly more retrieved oocytes than A1, but no difference in good-quality oocytes, retrieved embryos, top-quality embryos, or pregnancy outcomes. Group B2 had a significantly higher number of retrieved oocytes [11 (8.25, 15.5) vs. 6.50 (3.75, 8.25), p = 0.001], good-quality oocytes [8.5 (6.25, 10.5) vs. 5 (1.75, 6), p = 0.001], retrieved embryos [5 (4, 8.5) vs. 3.75 (1.75, 4.25), p = 0.011] and top-quality embryos [4.5 (3, 6) vs. 3 (1, 4), p = 0.023], compared to Group B1, respectively. The positive correlation between high E2 levels and ART outcomes persisted after adjusting for potential confounders. Higher E2 levels on DFOM are linked to better oocyte and embryo outcomes, especially in patients without TAI, but don’t correlate with improved pregnancy outcomes.https://doi.org/10.1038/s41598-025-04991-5EstradiolThyroid autoimmunityAssisted reproductive technologyPregnancy outcomes in ARTSerum estradiol levels on the day of final oocyte maturationThyroid autoimmunity and ART |
| spellingShingle | Sanja Medenica Durairaj Arjunan Eliana Garalejic Pinaki Dutta Milos Zarkovic Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity Scientific Reports Estradiol Thyroid autoimmunity Assisted reproductive technology Pregnancy outcomes in ART Serum estradiol levels on the day of final oocyte maturation Thyroid autoimmunity and ART |
| title | Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| title_full | Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| title_fullStr | Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| title_full_unstemmed | Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| title_short | Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| title_sort | serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity |
| topic | Estradiol Thyroid autoimmunity Assisted reproductive technology Pregnancy outcomes in ART Serum estradiol levels on the day of final oocyte maturation Thyroid autoimmunity and ART |
| url | https://doi.org/10.1038/s41598-025-04991-5 |
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