Electrochemical Detection of Caffeic Acid on Diethyl 3,4-Dihydroxythiophene-2,5-Dicarboxylate-Modified Carbon Paste Electrode: Insights from Computational Analysis

Electrochemical Detection of Caffeic Acid on Diethyl 3,4-Dihydroxythiophene-2,5-Dicarboxylate-Modified Carbon Paste Electrode: Insights from Computational Analysis

This study presents the electrochemical detection of caffeic acid using an ester (Diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate)-modified carbon paste electrode (EMCPE). Caffeic acid, a naturally occurring hydroxycinnamic acid with antioxidant properties, was investigated due to its significance...

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Bibliographic Details
Main Authors: Surya Chethana Suresh, Gururaj Kudur Jayaprakash, Sunitha Mughalihalli Shivashankar, Rajendrachari Shashanka, Bhavana Rikhari
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Electrochem
Subjects:
voltammetry
sensors
carbon paste
DFT
caffeic acid
Online Access:https://www.mdpi.com/2673-3293/6/2/19
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Summary:This study presents the electrochemical detection of caffeic acid using an ester (Diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate)-modified carbon paste electrode (EMCPE). Caffeic acid, a naturally occurring hydroxycinnamic acid with antioxidant properties, was investigated due to its significance in food products and its potential health benefits. The modified electrode demonstrated enhanced sensitivity and selectivity for caffeic acid detection. Voltammetric methods were applied to evaluate the electrode performance. Results indicated that EMCPE has improved electron transfer kinetics and a lower detection limit compared unmodified electrode. Detection and quantification thresholds (LOD and LOQ) were found to be <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>3.12</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>6</mn></mrow></msup></mrow></semantics></math></inline-formula> M and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1.04</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>3</mn></mrow></msup></mrow></semantics></math></inline-formula> M. Density functional theory used to understand the electron transfer properties of Diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate. The study highlights the potential of EMCPE as a reliable and cost-effective sensor to quantify caffeic acid across different sample matrices.
ISSN:2673-3293

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