Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors
Abstract Background The present study was conducted from 2021 to 2023 to analyze the clinical and laboratory characteristics of neurosyphilis and determine the risk factors associated with this condition. Methods A total of 400 patients were enrolled, including 100 individuals diagnosed with neurosy...
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| Language: | English |
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BMC
2025-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02349-1 |
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| author | Ekaterina Orlova Igor Gadaev Lyudmila Smirnova Natalia Kolenko Elena Zykova |
| author_facet | Ekaterina Orlova Igor Gadaev Lyudmila Smirnova Natalia Kolenko Elena Zykova |
| author_sort | Ekaterina Orlova |
| collection | DOAJ |
| description | Abstract Background The present study was conducted from 2021 to 2023 to analyze the clinical and laboratory characteristics of neurosyphilis and determine the risk factors associated with this condition. Methods A total of 400 patients were enrolled, including 100 individuals diagnosed with neurosyphilis, 100 without neurosyphilis, 100 with latent syphilis, and 100 healthy control subjects. Comparative analysis methods, serum VDRL titration, and correlation analysis were employed during the study. Results The analysis revealed significant differences in symptoms of central nervous system (CNS) involvement and serum VDRL titers among the patient groups. For instance, symptoms indicative of CNS impairment were more frequently observed in patients with neurosyphilis, and serum VDRL titers were statistically significantly higher in this same group. Conclusions The obtained results can be utilized in clinical practice to enhance the accuracy of neurosyphilis diagnosis and management, thereby contributing to the improvement of early detection of this condition and prevention of its complications. The study allows for the inference of the importance of early detection of (CNS) dysfunction symptoms in patients (neurosyphilis) with syphilis and identifies key factors influencing the development of this disease. The findings hold significance for the diagnosis and treatment of neurosyphilis. |
| format | Article |
| id | doaj-art-5440fb730ebf405d85ac783befb40d2c |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-5440fb730ebf405d85ac783befb40d2c2025-08-20T03:03:57ZengBMCEuropean Journal of Medical Research2047-783X2025-02-0130111010.1186/s40001-025-02349-1Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factorsEkaterina Orlova0Igor Gadaev1Lyudmila Smirnova2Natalia Kolenko3Elena Zykova4Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)Department of Hospital Therapy No. 1 Clinical Medicine Institute N.V. Sklifosovsky, I. M. Sechenov First Moscow State Medical University (Sechenov University)Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University (Sechenov University)Department of Nursing Management, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)Department of Biochemistry, I. M. Sechenov First Moscow State Medical University (Sechenov University)Abstract Background The present study was conducted from 2021 to 2023 to analyze the clinical and laboratory characteristics of neurosyphilis and determine the risk factors associated with this condition. Methods A total of 400 patients were enrolled, including 100 individuals diagnosed with neurosyphilis, 100 without neurosyphilis, 100 with latent syphilis, and 100 healthy control subjects. Comparative analysis methods, serum VDRL titration, and correlation analysis were employed during the study. Results The analysis revealed significant differences in symptoms of central nervous system (CNS) involvement and serum VDRL titers among the patient groups. For instance, symptoms indicative of CNS impairment were more frequently observed in patients with neurosyphilis, and serum VDRL titers were statistically significantly higher in this same group. Conclusions The obtained results can be utilized in clinical practice to enhance the accuracy of neurosyphilis diagnosis and management, thereby contributing to the improvement of early detection of this condition and prevention of its complications. The study allows for the inference of the importance of early detection of (CNS) dysfunction symptoms in patients (neurosyphilis) with syphilis and identifies key factors influencing the development of this disease. The findings hold significance for the diagnosis and treatment of neurosyphilis.https://doi.org/10.1186/s40001-025-02349-1Clinical characteristicsCNSDiagnosisNeurosyphilisRisk development |
| spellingShingle | Ekaterina Orlova Igor Gadaev Lyudmila Smirnova Natalia Kolenko Elena Zykova Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors European Journal of Medical Research Clinical characteristics CNS Diagnosis Neurosyphilis Risk development |
| title | Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors |
| title_full | Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors |
| title_fullStr | Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors |
| title_full_unstemmed | Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors |
| title_short | Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors |
| title_sort | clinical and laboratory characteristics of neurosyphilis analysis of symptoms and risk factors |
| topic | Clinical characteristics CNS Diagnosis Neurosyphilis Risk development |
| url | https://doi.org/10.1186/s40001-025-02349-1 |
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