Vitamin D insufficiency among children with cancer in India
Background: Vitamin D plays an important role in regulating various homeostatic mechanisms and has yet untapped potential in cancer prevention and prognosis. Only a few studies have been done worldwide in relating the Vitamin D levels in pediatric cancer patients to the general population but none s...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=1;spage=14;epage=19;aulast=Mohan |
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| author | Ram Mohan Gem Mohan Julius Xavier Scott Aruna Rajendran Venkatraman Paramasivam Manipriya Ravindran |
| author_facet | Ram Mohan Gem Mohan Julius Xavier Scott Aruna Rajendran Venkatraman Paramasivam Manipriya Ravindran |
| author_sort | Ram Mohan |
| collection | DOAJ |
| description | Background: Vitamin D plays an important role in regulating various homeostatic mechanisms and has yet untapped potential in cancer prevention and prognosis. Only a few studies have been done worldwide in relating the Vitamin D levels in pediatric cancer patients to the general population but none so far in an Indian setting to the best of our knowledge. Objective: To compare the Vitamin D levels in a group of children with cancer to that of the general pediatric population and to note differences in the prevalence of Vitamin D insufficiency and make inferences arising from demographic and therapeutic variations. Materials and Methods: Vitamin D levels were found by immuno-chemilumino-metric assay in 102 children (51 cases and 51 controls) over a 6 months period. Results: In comparing the Vitamin D levels of children with cancer and controls from a healthy population we found an increased incidence of Vitamin D insufficiency in cancer children (80.39%) when compared to controls (50.98%) and a much lower mean Vitamin D value in cancer children (22.8 ng/ml) when compared to controls (33 ng/dl). It was also found that cancer children above 6 years had a greater chance for developing Vitamin D insufficiency (P = 0.038) as did children suffering from hematological malignancies (P = 0.025). Conclusion: Our study showed an increased prevalence of Vitamin D insufficiency in children with cancer and hence we suggest routine measurement of Vitamin D levels in children with cancer and subsequent supplementation. |
| format | Article |
| id | doaj-art-543a1115b5d6465cbaba4d4bc9e3fe05 |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-543a1115b5d6465cbaba4d4bc9e3fe052025-08-20T01:57:20ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512016-01-01371141910.4103/0971-5851.177009Vitamin D insufficiency among children with cancer in IndiaRam MohanGem MohanJulius Xavier ScottAruna RajendranVenkatraman ParamasivamManipriya RavindranBackground: Vitamin D plays an important role in regulating various homeostatic mechanisms and has yet untapped potential in cancer prevention and prognosis. Only a few studies have been done worldwide in relating the Vitamin D levels in pediatric cancer patients to the general population but none so far in an Indian setting to the best of our knowledge. Objective: To compare the Vitamin D levels in a group of children with cancer to that of the general pediatric population and to note differences in the prevalence of Vitamin D insufficiency and make inferences arising from demographic and therapeutic variations. Materials and Methods: Vitamin D levels were found by immuno-chemilumino-metric assay in 102 children (51 cases and 51 controls) over a 6 months period. Results: In comparing the Vitamin D levels of children with cancer and controls from a healthy population we found an increased incidence of Vitamin D insufficiency in cancer children (80.39%) when compared to controls (50.98%) and a much lower mean Vitamin D value in cancer children (22.8 ng/ml) when compared to controls (33 ng/dl). It was also found that cancer children above 6 years had a greater chance for developing Vitamin D insufficiency (P = 0.038) as did children suffering from hematological malignancies (P = 0.025). Conclusion: Our study showed an increased prevalence of Vitamin D insufficiency in children with cancer and hence we suggest routine measurement of Vitamin D levels in children with cancer and subsequent supplementation.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=1;spage=14;epage=19;aulast=MohanChildhood cancerIndiaVitamin D |
| spellingShingle | Ram Mohan Gem Mohan Julius Xavier Scott Aruna Rajendran Venkatraman Paramasivam Manipriya Ravindran Vitamin D insufficiency among children with cancer in India Indian Journal of Medical and Paediatric Oncology Childhood cancer India Vitamin D |
| title | Vitamin D insufficiency among children with cancer in India |
| title_full | Vitamin D insufficiency among children with cancer in India |
| title_fullStr | Vitamin D insufficiency among children with cancer in India |
| title_full_unstemmed | Vitamin D insufficiency among children with cancer in India |
| title_short | Vitamin D insufficiency among children with cancer in India |
| title_sort | vitamin d insufficiency among children with cancer in india |
| topic | Childhood cancer India Vitamin D |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=1;spage=14;epage=19;aulast=Mohan |
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