Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4

Abstract The human relaxin family peptide receptors RXFP3 and RXFP4 play important physiological roles through interactions with endogenous hormones, relaxin-3 and insulin-like peptide 5 (INSL5). They are implicated in certain neurological and metabolic disorders. While INSL5 only activates RXFP4, r...

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Bibliographic Details
Main Authors: Yan Chen, Qingtong Zhou, Shiyu Yan, Jiahui Yan, Dehua Yang, Jian Chen, Ming-Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08220-7
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