So close yet so far apart: distinct flanking sequence recognition by DNMT3A and DNMT3B
Abstract DNMT3A and DNMT3B are closely related DNA methyltransferases that catalyze de novo CpG methylation and have distinct preferences for flanking sequences. Despite sharing 91% sequence similarity within their catalytic domains, these paralogs show non-overlapping genomic targeting and divergen...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08606-7 |
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