Western and complementary alternative medicine treatment of uremic pruritus: A literature review
Uremic pruritus (UP), also called chronic kidney disease-associated pruritus (CKD-aP), is a bothersome symptom that causes sleep disturbance, anxiety, depression, and reduced quality of life. Pruritus often occurs in patients with end-stage renal disease. There is still no definite treatment for UP...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=350;epage=358;aulast=Lu |
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| author | Ping-Hsun Lu Yu-Chih Tai Min-Chien Yu I-Hsin Lin Ko-Lin Kuo |
| author_facet | Ping-Hsun Lu Yu-Chih Tai Min-Chien Yu I-Hsin Lin Ko-Lin Kuo |
| author_sort | Ping-Hsun Lu |
| collection | DOAJ |
| description | Uremic pruritus (UP), also called chronic kidney disease-associated pruritus (CKD-aP), is a bothersome symptom that causes sleep disturbance, anxiety, depression, and reduced quality of life. Pruritus often occurs in patients with end-stage renal disease. There is still no definite treatment for UP due to its unclear pathogenesis. We searched electronic databases (PubMed and Google Scholar) and gathered the latest clinical trials and pilot studies of Western and complementary alternative medicine (CAM) therapies for UP in English. These UP studies were separated into three main groups: systemic, topical, and others and CAM. Gabapentin, nalfurafine, acupuncture, and Chinese herbal bath therapy (CHBT) show antipruritic effects, with higher evidence grades in the meta-analysis. Emollients with additive compounds are more effective for reducing itch than emollients without additives. Supplements for deficient elements, such as zinc, omega-3, and omega-6, also show benefits for pruritus improvement. CAM therapies such as acupuncture, herbs, and herbal baths or creams all have good results for UP treatment. We summarize the treatments and suggest a treatment algorithm for UP according to severity. Some UP therapies are already supported by large-scale clinical evidence, and some new treatments can provide patients with new hope and treatment options. However, these new methods still need large population studies and further exploration. |
| format | Article |
| id | doaj-art-542fa2ee75f14d7796c9c90e2283af66 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-542fa2ee75f14d7796c9c90e2283af662025-08-20T02:15:54ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562021-01-0133435035810.4103/tcmj.tcmj_151_20Western and complementary alternative medicine treatment of uremic pruritus: A literature reviewPing-Hsun LuYu-Chih TaiMin-Chien YuI-Hsin LinKo-Lin KuoUremic pruritus (UP), also called chronic kidney disease-associated pruritus (CKD-aP), is a bothersome symptom that causes sleep disturbance, anxiety, depression, and reduced quality of life. Pruritus often occurs in patients with end-stage renal disease. There is still no definite treatment for UP due to its unclear pathogenesis. We searched electronic databases (PubMed and Google Scholar) and gathered the latest clinical trials and pilot studies of Western and complementary alternative medicine (CAM) therapies for UP in English. These UP studies were separated into three main groups: systemic, topical, and others and CAM. Gabapentin, nalfurafine, acupuncture, and Chinese herbal bath therapy (CHBT) show antipruritic effects, with higher evidence grades in the meta-analysis. Emollients with additive compounds are more effective for reducing itch than emollients without additives. Supplements for deficient elements, such as zinc, omega-3, and omega-6, also show benefits for pruritus improvement. CAM therapies such as acupuncture, herbs, and herbal baths or creams all have good results for UP treatment. We summarize the treatments and suggest a treatment algorithm for UP according to severity. Some UP therapies are already supported by large-scale clinical evidence, and some new treatments can provide patients with new hope and treatment options. However, these new methods still need large population studies and further exploration.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=350;epage=358;aulast=Luchronic kidney diseasecomplementary and alternative medicinedialysisend-stage renal diseaseuremic pruritus |
| spellingShingle | Ping-Hsun Lu Yu-Chih Tai Min-Chien Yu I-Hsin Lin Ko-Lin Kuo Western and complementary alternative medicine treatment of uremic pruritus: A literature review Tzu Chi Medical Journal chronic kidney disease complementary and alternative medicine dialysis end-stage renal disease uremic pruritus |
| title | Western and complementary alternative medicine treatment of uremic pruritus: A literature review |
| title_full | Western and complementary alternative medicine treatment of uremic pruritus: A literature review |
| title_fullStr | Western and complementary alternative medicine treatment of uremic pruritus: A literature review |
| title_full_unstemmed | Western and complementary alternative medicine treatment of uremic pruritus: A literature review |
| title_short | Western and complementary alternative medicine treatment of uremic pruritus: A literature review |
| title_sort | western and complementary alternative medicine treatment of uremic pruritus a literature review |
| topic | chronic kidney disease complementary and alternative medicine dialysis end-stage renal disease uremic pruritus |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=350;epage=358;aulast=Lu |
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