Multi-omics profiling of acute Pseudomonas aeruginosa pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets

Multi-omics profiling of acute Pseudomonas aeruginosa pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets

Pseudomonas aeruginosa (PA) is a key pathogen in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), challenging clinical medicine. This study aims to elucidate the characteristics of the host’s innate immune response following inhalational PA infection. We developed a mouse...

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Bibliographic Details
Main Authors: Fuliang Zong, Nan Xiao, Yifeng Wang, Duo Su, Dongsheng Zhou, Lingfei Hu, Huiying Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Virulence
Subjects:
Pseudomonas aeruginosa
aerosolized intratracheal inoculation
conventional NK cells
innate immunity
RNA-sequencing
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2025.2490206
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