Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers
Microfluidic technology has transformed the synthesis of core-shell nanoparticles (CSNPs), providing an unprecedented level of control over their structural and functional properties. This review critically evaluates recent advancements, highlighting the superiority of microfluidic methods over conv...
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| Language: | English |
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Elsevier
2025-05-01
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| Series: | Chemical Engineering Journal Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666821125000560 |
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| author | Giuseppe Nunziata Alessandro Borroni Filippo Rossi |
| author_facet | Giuseppe Nunziata Alessandro Borroni Filippo Rossi |
| author_sort | Giuseppe Nunziata |
| collection | DOAJ |
| description | Microfluidic technology has transformed the synthesis of core-shell nanoparticles (CSNPs), providing an unprecedented level of control over their structural and functional properties. This review critically evaluates recent advancements, highlighting the superiority of microfluidic methods over conventional batch techniques, which often suffer from variability and scalability issues. Indeed microfluidic platforms enable the precise manipulation of reaction conditions, leading to highly uniform nanoparticles with optimized characteristics. This level of precision is particularly relevant in drug delivery, where the ability to fine-tune nanoparticle size, composition, and surface properties directly influences therapeutic efficacy. A fundamental aspect of this approach lies in the choice of synthesis techniques, such as nanoprecipitation and emulsification, which leverage the confined microscale environment to promote controlled self-assembly. Equally important is the selection of materials for microfluidic chip fabrication, as properties such as chemical resistance, biocompatibility, and manufacturability determine the feasibility of large-scale production. The integration of microfluidics into nanoparticle production is not merely a technical refinement but a step toward a more efficient and adaptable nanomedicine. By integrating these strategies, microfluidics emerges as a key enabler for the clinical translation of nanomedicine. To bridge the gap between lab-scale synthesis and industrial production, this review discusses high-throughput microfluidic platforms and multilayered designs. |
| format | Article |
| id | doaj-art-54249688a16d4daa8e7f01ab5300cdc3 |
| institution | DOAJ |
| issn | 2666-8211 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Engineering Journal Advances |
| spelling | doaj-art-54249688a16d4daa8e7f01ab5300cdc32025-08-20T03:13:49ZengElsevierChemical Engineering Journal Advances2666-82112025-05-012210075910.1016/j.ceja.2025.100759Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriersGiuseppe Nunziata0Alessandro Borroni1Filippo Rossi2Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, ItalyDepartment of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, ItalyCorresponding author.; Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, ItalyMicrofluidic technology has transformed the synthesis of core-shell nanoparticles (CSNPs), providing an unprecedented level of control over their structural and functional properties. This review critically evaluates recent advancements, highlighting the superiority of microfluidic methods over conventional batch techniques, which often suffer from variability and scalability issues. Indeed microfluidic platforms enable the precise manipulation of reaction conditions, leading to highly uniform nanoparticles with optimized characteristics. This level of precision is particularly relevant in drug delivery, where the ability to fine-tune nanoparticle size, composition, and surface properties directly influences therapeutic efficacy. A fundamental aspect of this approach lies in the choice of synthesis techniques, such as nanoprecipitation and emulsification, which leverage the confined microscale environment to promote controlled self-assembly. Equally important is the selection of materials for microfluidic chip fabrication, as properties such as chemical resistance, biocompatibility, and manufacturability determine the feasibility of large-scale production. The integration of microfluidics into nanoparticle production is not merely a technical refinement but a step toward a more efficient and adaptable nanomedicine. By integrating these strategies, microfluidics emerges as a key enabler for the clinical translation of nanomedicine. To bridge the gap between lab-scale synthesis and industrial production, this review discusses high-throughput microfluidic platforms and multilayered designs.http://www.sciencedirect.com/science/article/pii/S2666821125000560ColloidsFlow chemistryPolymersNanoparticlesProcess intensification |
| spellingShingle | Giuseppe Nunziata Alessandro Borroni Filippo Rossi Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers Chemical Engineering Journal Advances Colloids Flow chemistry Polymers Nanoparticles Process intensification |
| title | Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers |
| title_full | Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers |
| title_fullStr | Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers |
| title_full_unstemmed | Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers |
| title_short | Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers |
| title_sort | advanced microfluidic strategies for core shell nanoparticles the next generation of polymeric and lipid based drug nanocarriers |
| topic | Colloids Flow chemistry Polymers Nanoparticles Process intensification |
| url | http://www.sciencedirect.com/science/article/pii/S2666821125000560 |
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