Biotransformation of anthelmintics in nematodes in relation to drug resistance
In all organisms, the biotransformation of xenobiotics to less toxic and more hydrophilic compounds represents an effective defense strategy. In pathogens, the biotransformation of drugs (used for their elimination from the host) may provide undesirable protective effects that could potentially comp...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | International Journal for Parasitology: Drugs and Drug Resistance |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211320725000028 |
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| author | Ondřej Vosála Josef Krátký Petra Matoušková Nikola Rychlá Karolína Štěrbová Lucie Raisová Stuchlíková Ivan Vokřál Lenka Skálová |
| author_facet | Ondřej Vosála Josef Krátký Petra Matoušková Nikola Rychlá Karolína Štěrbová Lucie Raisová Stuchlíková Ivan Vokřál Lenka Skálová |
| author_sort | Ondřej Vosála |
| collection | DOAJ |
| description | In all organisms, the biotransformation of xenobiotics to less toxic and more hydrophilic compounds represents an effective defense strategy. In pathogens, the biotransformation of drugs (used for their elimination from the host) may provide undesirable protective effects that could potentially compromise the drug's efficacy. Accordingly, increased drug deactivation via accelerated biotransformation is now considered as one of the mechanisms of drug resistance. The present study summarizes the current knowledge regarding the biotransformation of anthelmintics, specifically drugs used to treat mainly nematodes, a group of parasites that are a significant health concern for humans and animals. The main biotransformation enzymes are introduced and their roles in anthelmintics metabolism in nematodes are discussed with a particular focus on their potential participation in drug resistance. Similarly, the inducibility of biotransformation enzymes with sublethal doses of anthelmintics is presented in view of its potential contribution to drug resistance development. In the conclusion, the main tasks awaiting scientists in this area are outlined. |
| format | Article |
| id | doaj-art-5423248f11ca448ebc5d2dc438ccaf7e |
| institution | OA Journals |
| issn | 2211-3207 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal for Parasitology: Drugs and Drug Resistance |
| spelling | doaj-art-5423248f11ca448ebc5d2dc438ccaf7e2025-08-20T02:16:44ZengElsevierInternational Journal for Parasitology: Drugs and Drug Resistance2211-32072025-04-012710057910.1016/j.ijpddr.2025.100579Biotransformation of anthelmintics in nematodes in relation to drug resistanceOndřej Vosála0Josef Krátký1Petra Matoušková2Nikola Rychlá3Karolína Štěrbová4Lucie Raisová Stuchlíková5Ivan Vokřál6Lenka Skálová7Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech RepublicDepartment of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech Republic; Corresponding author.In all organisms, the biotransformation of xenobiotics to less toxic and more hydrophilic compounds represents an effective defense strategy. In pathogens, the biotransformation of drugs (used for their elimination from the host) may provide undesirable protective effects that could potentially compromise the drug's efficacy. Accordingly, increased drug deactivation via accelerated biotransformation is now considered as one of the mechanisms of drug resistance. The present study summarizes the current knowledge regarding the biotransformation of anthelmintics, specifically drugs used to treat mainly nematodes, a group of parasites that are a significant health concern for humans and animals. The main biotransformation enzymes are introduced and their roles in anthelmintics metabolism in nematodes are discussed with a particular focus on their potential participation in drug resistance. Similarly, the inducibility of biotransformation enzymes with sublethal doses of anthelmintics is presented in view of its potential contribution to drug resistance development. In the conclusion, the main tasks awaiting scientists in this area are outlined.http://www.sciencedirect.com/science/article/pii/S2211320725000028 |
| spellingShingle | Ondřej Vosála Josef Krátký Petra Matoušková Nikola Rychlá Karolína Štěrbová Lucie Raisová Stuchlíková Ivan Vokřál Lenka Skálová Biotransformation of anthelmintics in nematodes in relation to drug resistance International Journal for Parasitology: Drugs and Drug Resistance |
| title | Biotransformation of anthelmintics in nematodes in relation to drug resistance |
| title_full | Biotransformation of anthelmintics in nematodes in relation to drug resistance |
| title_fullStr | Biotransformation of anthelmintics in nematodes in relation to drug resistance |
| title_full_unstemmed | Biotransformation of anthelmintics in nematodes in relation to drug resistance |
| title_short | Biotransformation of anthelmintics in nematodes in relation to drug resistance |
| title_sort | biotransformation of anthelmintics in nematodes in relation to drug resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2211320725000028 |
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