Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II)

Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II)

Introduction Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Over the past 20 years, a number of new drugs have been approved for National Health Service (NHS) use on the basis of information from short-term trials that demonstrate efficacy. These trials do not provide information...

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Main Authors: Girvan Burnside, Munir Pirmohamed, Dyfrig A Hughes, Paula R Williamson, Anthony Guy Marson, Claire Taylor, Phil E M Smith, John Paul Leach, Gus Baker, Catrin Tudur-Smith, Richard Appleton, Michael Johnson, Silviya Balabanova, Graeme Sills, Catrin Plumpton
Format: Article
Language:English
Published: BMJ Publishing Group 2020-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/8/e040635.full
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