Urban parks biowaste as a sustainable source of new antidiabetics
Biowaste produced in urban parks is composed of large masses of organic matter that is only occasionally used economically. In this work, extracts of six plants widely distributed in urban parks in Central Europe (Achillea millefolium, Cichorium intybus, Malva sylvestris, Medicago sativa, Plantago l...
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2024-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0039 |
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| author | Marijan Marijan Jakupović Lejsa Vujić Lovorka Jurić Marina Končić Marijana Zovko |
| author_facet | Marijan Marijan Jakupović Lejsa Vujić Lovorka Jurić Marina Končić Marijana Zovko |
| author_sort | Marijan Marijan |
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| description | Biowaste produced in urban parks is composed of large masses of organic matter that is only occasionally used economically. In this work, extracts of six plants widely distributed in urban parks in Central Europe (Achillea millefolium, Cichorium intybus, Malva sylvestris, Medicago sativa, Plantago lanceolata, and Trifolium pratense), prepared using 10 % and 50 % ethanol, were screened for their antidiabetic and related properties. HPLC and UV-Vis analysis revealed the presence of caffeic acid, quercetin, luteolin, and apigenin derivatives. The extracts were active in DPPH antiradical, β-carotene-linoleic acid, ORAC, and reducing power assay. They inhibited lipoxygenase, collagenase, as well as heat-induced ovalbumin coagulation. They were also able to hinder carbohydrate degradation. For example, IC50 of anti-α-amylase activity of 10 % and 50 % ethanol extract of M. sativa extracts (204.10 ± 2.11 µg mL−1 and 78.27 ± 0.99 µg mL−1, respectively) did not statistically differ from the activity of the positive control, acarbose (284.74 ± 3.81 µg mL−1). Similar results were observed for their anti-α-glucosidase activity. In most assays, the use of 50 % ethanol was shown to be better suited for the extraction of active metabolites. The results indicate that the biowaste obtained from urban parks represents a potential source of plant material for the preparation of high-value antidiabetic products. |
| format | Article |
| id | doaj-art-541be92a3e83461d937cfd6efeb3d718 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sciendo |
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| series | Acta Pharmaceutica |
| spelling | doaj-art-541be92a3e83461d937cfd6efeb3d7182025-02-02T15:47:25ZengSciendoActa Pharmaceutica1846-95582024-12-0174461363310.2478/acph-2024-0039Urban parks biowaste as a sustainable source of new antidiabeticsMarijan Marijan0Jakupović Lejsa1Vujić Lovorka2Jurić Marina3Končić Marijana Zovko4University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and Biochemistry Department of Nutrition and Dietetics, 10000ZagrebCroatiaUniversity of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy10000Zagreb, CroatiaBiowaste produced in urban parks is composed of large masses of organic matter that is only occasionally used economically. In this work, extracts of six plants widely distributed in urban parks in Central Europe (Achillea millefolium, Cichorium intybus, Malva sylvestris, Medicago sativa, Plantago lanceolata, and Trifolium pratense), prepared using 10 % and 50 % ethanol, were screened for their antidiabetic and related properties. HPLC and UV-Vis analysis revealed the presence of caffeic acid, quercetin, luteolin, and apigenin derivatives. The extracts were active in DPPH antiradical, β-carotene-linoleic acid, ORAC, and reducing power assay. They inhibited lipoxygenase, collagenase, as well as heat-induced ovalbumin coagulation. They were also able to hinder carbohydrate degradation. For example, IC50 of anti-α-amylase activity of 10 % and 50 % ethanol extract of M. sativa extracts (204.10 ± 2.11 µg mL−1 and 78.27 ± 0.99 µg mL−1, respectively) did not statistically differ from the activity of the positive control, acarbose (284.74 ± 3.81 µg mL−1). Similar results were observed for their anti-α-glucosidase activity. In most assays, the use of 50 % ethanol was shown to be better suited for the extraction of active metabolites. The results indicate that the biowaste obtained from urban parks represents a potential source of plant material for the preparation of high-value antidiabetic products.https://doi.org/10.2478/acph-2024-0039antidiabeticantihyperglycemicanti-inflammatoryhplcnatural phenolswaste management |
| spellingShingle | Marijan Marijan Jakupović Lejsa Vujić Lovorka Jurić Marina Končić Marijana Zovko Urban parks biowaste as a sustainable source of new antidiabetics Acta Pharmaceutica antidiabetic antihyperglycemic anti-inflammatory hplc natural phenols waste management |
| title | Urban parks biowaste as a sustainable source of new antidiabetics |
| title_full | Urban parks biowaste as a sustainable source of new antidiabetics |
| title_fullStr | Urban parks biowaste as a sustainable source of new antidiabetics |
| title_full_unstemmed | Urban parks biowaste as a sustainable source of new antidiabetics |
| title_short | Urban parks biowaste as a sustainable source of new antidiabetics |
| title_sort | urban parks biowaste as a sustainable source of new antidiabetics |
| topic | antidiabetic antihyperglycemic anti-inflammatory hplc natural phenols waste management |
| url | https://doi.org/10.2478/acph-2024-0039 |
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