Inhibition of TNF-α Reverses the Pathological Resorption Pit Profile of Osteoclasts from Patients with Acute Charcot Osteoarthropathy
We hypothesised that tumour necrosis factor-α (TNF-α) may enhance receptor activator of nuclear factor-κβ ligand- (RANKL-) mediated osteoclastogenesis in acute Charcot osteoarthropathy. Peripheral blood monocytes were isolated from 10 acute Charcot patients, 8 diabetic patients, and 9 healthy contro...
Saved in:
| Main Authors: | Nina L. Petrova, Peter K. Petrov, Michael E. Edmonds, Catherine M. Shanahan |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/917945 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo
by: Hideki Kitaura, et al.
Published: (2013-01-01) -
Infrared Dermal Thermometry in Active Charcot Neuro-Osteoarthropathy of Foot
by: Jayaditya Ghosh, et al.
Published: (2025-05-01) -
Criteria of immobilization duration of the affected foot in diabetic Charcot neuro-osteoarthropathy
by: Anastasia Gennad'evna Demina, et al.
Published: (2014-12-01) -
The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-α Expression in Macrophages
by: Wei-Ren Shen, et al.
Published: (2018-01-01) -
Radiological Assessment of Charcot Neuro-Osteoarthropathy in Diabetic Foot: A Narrative Review
by: Antonio Mascio, et al.
Published: (2025-03-01)