MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.
MicroRNA-214 (miR-214) has been reported to be dysregulated in human bladder cancer tissues. We aimed to investigate the clinical correlation, biological significance and molecular network of miR-214 in bladder cancer. Our results showed miR-214 was down-regulated in bladder cancer tissues and signi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118086&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191029045559296 |
|---|---|
| author | Jinfeng Wang Xin Zhang Lili Wang Yongmei Yang Zhaogang Dong Haiyan Wang Lutao Du Chuanxin Wang |
| author_facet | Jinfeng Wang Xin Zhang Lili Wang Yongmei Yang Zhaogang Dong Haiyan Wang Lutao Du Chuanxin Wang |
| author_sort | Jinfeng Wang |
| collection | DOAJ |
| description | MicroRNA-214 (miR-214) has been reported to be dysregulated in human bladder cancer tissues. We aimed to investigate the clinical correlation, biological significance and molecular network of miR-214 in bladder cancer. Our results showed miR-214 was down-regulated in bladder cancer tissues and significantly associated with tumor stage, lymph node status, grade, multifocality, history of non-muscle-invasive bladder cancer (NMIBC). Moreover, miR-214 could serve as an independent factor of recurrence-free survival (RFS) and overall survival (OS) for patients with muscle-invasive bladder cancer (MIBC). Restoration of miR-214 expression in bladder cancer cell lines inhibited cell proliferation, migration, invasion and markedly promoted apoptosis. Dual-luciferase reporter assay recognized PDRG1 as direct downstream target gene of miR-214. PDRG1 was significantly increased in tumors low of miR-214 and knockdown of PDRG1 mimicked the effects of miR-214 overexpression. Our findings manifest that miR-214 could exert tumor-suppressive effects in bladder cancer by directly down-regulating oncogene PDRG1 and suggest an appealing novel indicator for prognostic and therapeutic intervention of bladder cancer. |
| format | Article |
| id | doaj-art-5418d35d348d4e6691438f6ca0f1f736 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5418d35d348d4e6691438f6ca0f1f7362025-08-20T02:15:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011808610.1371/journal.pone.0118086MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.Jinfeng WangXin ZhangLili WangYongmei YangZhaogang DongHaiyan WangLutao DuChuanxin WangMicroRNA-214 (miR-214) has been reported to be dysregulated in human bladder cancer tissues. We aimed to investigate the clinical correlation, biological significance and molecular network of miR-214 in bladder cancer. Our results showed miR-214 was down-regulated in bladder cancer tissues and significantly associated with tumor stage, lymph node status, grade, multifocality, history of non-muscle-invasive bladder cancer (NMIBC). Moreover, miR-214 could serve as an independent factor of recurrence-free survival (RFS) and overall survival (OS) for patients with muscle-invasive bladder cancer (MIBC). Restoration of miR-214 expression in bladder cancer cell lines inhibited cell proliferation, migration, invasion and markedly promoted apoptosis. Dual-luciferase reporter assay recognized PDRG1 as direct downstream target gene of miR-214. PDRG1 was significantly increased in tumors low of miR-214 and knockdown of PDRG1 mimicked the effects of miR-214 overexpression. Our findings manifest that miR-214 could exert tumor-suppressive effects in bladder cancer by directly down-regulating oncogene PDRG1 and suggest an appealing novel indicator for prognostic and therapeutic intervention of bladder cancer.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118086&type=printable |
| spellingShingle | Jinfeng Wang Xin Zhang Lili Wang Yongmei Yang Zhaogang Dong Haiyan Wang Lutao Du Chuanxin Wang MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. PLoS ONE |
| title | MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. |
| title_full | MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. |
| title_fullStr | MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. |
| title_full_unstemmed | MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. |
| title_short | MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. |
| title_sort | microrna 214 suppresses oncogenesis and exerts impact on prognosis by targeting pdrg1 in bladder cancer |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118086&type=printable |
| work_keys_str_mv | AT jinfengwang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT xinzhang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT liliwang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT yongmeiyang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT zhaogangdong microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT haiyanwang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT lutaodu microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer AT chuanxinwang microrna214suppressesoncogenesisandexertsimpactonprognosisbytargetingpdrg1inbladdercancer |