Meniere’s disease: an inner ear disease caused by multiple factors
Meniere’s disease (MD) is an inner ear disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, and aural fullness. The pathogenesis of MD remains unclear but is closely associated with endolymphatic hydrops (EH), immune dysregulation, genetic predisposition, vascular dysfunc...
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| Format: | Article |
| Language: | English |
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Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-04-01
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| Series: | Zhongguo Linchuang Yixue |
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| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250369 |
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| author | Huaili JIANG Xinsheng HUANG |
| author_facet | Huaili JIANG Xinsheng HUANG |
| author_sort | Huaili JIANG |
| collection | DOAJ |
| description | Meniere’s disease (MD) is an inner ear disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, and aural fullness. The pathogenesis of MD remains unclear but is closely associated with endolymphatic hydrops (EH), immune dysregulation, genetic predisposition, vascular dysfunction, and viral infection. This review summarizes recent research advances of MD pathogenesis, suggesting that MD may be a heterogeneous condition with distinct subtypes driven by different mechanisms. Future studies should integrate multi-omics analyses and animal models to elucidate its molecular pathways. |
| format | Article |
| id | doaj-art-541532b34b4f4433b2aaee2273a80bb3 |
| institution | OA Journals |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-541532b34b4f4433b2aaee2273a80bb32025-08-20T02:19:15ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-04-0132216116410.12025/j.issn.1008-6358.2025.2025036920250369Meniere’s disease: an inner ear disease caused by multiple factorsHuaili JIANG0Xinsheng HUANG1Department of Otolaryngology Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Otolaryngology Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaMeniere’s disease (MD) is an inner ear disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, and aural fullness. The pathogenesis of MD remains unclear but is closely associated with endolymphatic hydrops (EH), immune dysregulation, genetic predisposition, vascular dysfunction, and viral infection. This review summarizes recent research advances of MD pathogenesis, suggesting that MD may be a heterogeneous condition with distinct subtypes driven by different mechanisms. Future studies should integrate multi-omics analyses and animal models to elucidate its molecular pathways.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250369meniere’s diseaseendolymphatic hydropsimmune mechanismgenetic factormultifactorial interaction |
| spellingShingle | Huaili JIANG Xinsheng HUANG Meniere’s disease: an inner ear disease caused by multiple factors Zhongguo Linchuang Yixue meniere’s disease endolymphatic hydrops immune mechanism genetic factor multifactorial interaction |
| title | Meniere’s disease: an inner ear disease caused by multiple factors |
| title_full | Meniere’s disease: an inner ear disease caused by multiple factors |
| title_fullStr | Meniere’s disease: an inner ear disease caused by multiple factors |
| title_full_unstemmed | Meniere’s disease: an inner ear disease caused by multiple factors |
| title_short | Meniere’s disease: an inner ear disease caused by multiple factors |
| title_sort | meniere s disease an inner ear disease caused by multiple factors |
| topic | meniere’s disease endolymphatic hydrops immune mechanism genetic factor multifactorial interaction |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250369 |
| work_keys_str_mv | AT huailijiang menieresdiseaseaninnereardiseasecausedbymultiplefactors AT xinshenghuang menieresdiseaseaninnereardiseasecausedbymultiplefactors |