Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography
Abstract Introduction The aim of this study is to analyze the diagnostic value of global longitudinal strain (GLS) in detecting inducible myocardial ischemia in patients with chest pain undergoing treadmill contrast-enhanced stress echocardiography (SE). Methods We retrospectively enrolled all patie...
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BMC
2024-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-03926-8 |
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| author | Rami M. Abazid Nilkanth Patil Maged Elrayes Mark Chandy Magdi Hassanin Andrew Mathew Sabe De Rodrigo Bagur Nikolaos Tzemos |
| author_facet | Rami M. Abazid Nilkanth Patil Maged Elrayes Mark Chandy Magdi Hassanin Andrew Mathew Sabe De Rodrigo Bagur Nikolaos Tzemos |
| author_sort | Rami M. Abazid |
| collection | DOAJ |
| description | Abstract Introduction The aim of this study is to analyze the diagnostic value of global longitudinal strain (GLS) in detecting inducible myocardial ischemia in patients with chest pain undergoing treadmill contrast-enhanced stress echocardiography (SE). Methods We retrospectively enrolled all patients who underwent invasive coronary angiography after treadmill contrast-enhanced SE. Rest and peak-stress myocardial GLS, segmental LS, and LS of 4-chamber (CH), 2-CH, and 3-CH views were reported. Luminal stenosis of more than 70% or fractional flow reserve (FFR) of < 0.8 was considered significant. Results In total 33 patients were included in the final analysis, among whom sixteen patients (48.4%) had significant coronary artery stenosis. Averaged GLS, 3-CH, and 4-CH LS were significantly lower in patients with critical coronary artery stenosis compared to those without significant stenosis (-17.1 ± 7.1 vs. -24.2 ± 7.2, p = 0.041), (-18.2 ± 8.9 vs. -24.6 ± 8.2, p = 0.045) and (-14.8 ± 6.2 vs. -22.8 ± 7.8, p = 0.009), respectively. Receiver operating characteristic (ROC) analysis of ischemic and non-ischemic segments demonstrated that a cut-off value of -20% of stress LS had 71% sensitivity and 60% specificity for ruling out inducible myocardial ischemia (Area under the curve was AUC = 0.72, P < 0.0001). Conclusion Myocardial LS measured with treadmill contrast-enhanced stress echocardiography demonstrates potential value in identifying patients with inducible myocardial ischemia. |
| format | Article |
| id | doaj-art-540bc2a9f30a4fd6b85327df44e59b77 |
| institution | DOAJ |
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| language | English |
| publishDate | 2024-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-540bc2a9f30a4fd6b85327df44e59b772025-08-20T02:56:11ZengBMCBMC Cardiovascular Disorders1471-22612024-05-012411810.1186/s12872-024-03926-8Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiographyRami M. Abazid0Nilkanth Patil1Maged Elrayes2Mark Chandy3Magdi Hassanin4Andrew Mathew5Sabe De6Rodrigo Bagur7Nikolaos Tzemos8Northern Ontario Medical School (NOSM) University, Department of Medicine, Sault Area HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalNorthern Ontario Medical School (NOSM) University, Department of Medicine, Sault Area HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalDivision of Cardiology, Department of Medicine, London Health Sciences Centre, University HospitalAbstract Introduction The aim of this study is to analyze the diagnostic value of global longitudinal strain (GLS) in detecting inducible myocardial ischemia in patients with chest pain undergoing treadmill contrast-enhanced stress echocardiography (SE). Methods We retrospectively enrolled all patients who underwent invasive coronary angiography after treadmill contrast-enhanced SE. Rest and peak-stress myocardial GLS, segmental LS, and LS of 4-chamber (CH), 2-CH, and 3-CH views were reported. Luminal stenosis of more than 70% or fractional flow reserve (FFR) of < 0.8 was considered significant. Results In total 33 patients were included in the final analysis, among whom sixteen patients (48.4%) had significant coronary artery stenosis. Averaged GLS, 3-CH, and 4-CH LS were significantly lower in patients with critical coronary artery stenosis compared to those without significant stenosis (-17.1 ± 7.1 vs. -24.2 ± 7.2, p = 0.041), (-18.2 ± 8.9 vs. -24.6 ± 8.2, p = 0.045) and (-14.8 ± 6.2 vs. -22.8 ± 7.8, p = 0.009), respectively. Receiver operating characteristic (ROC) analysis of ischemic and non-ischemic segments demonstrated that a cut-off value of -20% of stress LS had 71% sensitivity and 60% specificity for ruling out inducible myocardial ischemia (Area under the curve was AUC = 0.72, P < 0.0001). Conclusion Myocardial LS measured with treadmill contrast-enhanced stress echocardiography demonstrates potential value in identifying patients with inducible myocardial ischemia.https://doi.org/10.1186/s12872-024-03926-8Myocardial strainTreadmillStress EchocardiographyContrast |
| spellingShingle | Rami M. Abazid Nilkanth Patil Maged Elrayes Mark Chandy Magdi Hassanin Andrew Mathew Sabe De Rodrigo Bagur Nikolaos Tzemos Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography BMC Cardiovascular Disorders Myocardial strain Treadmill Stress Echocardiography Contrast |
| title | Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography |
| title_full | Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography |
| title_fullStr | Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography |
| title_full_unstemmed | Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography |
| title_short | Role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast-enhanced stress echocardiography |
| title_sort | role of myocardial strain imaging in diagnosing inducible myocardial ischemia with treadmill contrast enhanced stress echocardiography |
| topic | Myocardial strain Treadmill Stress Echocardiography Contrast |
| url | https://doi.org/10.1186/s12872-024-03926-8 |
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