Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children
Intrauterine growth retardation (IUGR), the most important cause of perinatal mortality and morbidity, is defined as a foetal growth less than normal for the population, often used as synonym of small for gestational age (SGA). Studies demonstrated the relationships between metabolic syndrome (MS) a...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/269853 |
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| author | Anna Alisi Nadia Panera Carlo Agostoni Valerio Nobili |
| author_facet | Anna Alisi Nadia Panera Carlo Agostoni Valerio Nobili |
| author_sort | Anna Alisi |
| collection | DOAJ |
| description | Intrauterine growth retardation (IUGR), the most important cause of perinatal mortality and morbidity, is defined as a foetal growth less than normal for the population, often used as synonym of small for gestational age (SGA). Studies demonstrated the relationships between metabolic syndrome (MS) and birthweight. This study suggested that, in children, adolescents, and adults born SGA, insulin resistance could lead to other metabolic disorders: type 2 diabetes (DM2), dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). NAFLD may evolve to nonalcoholic steatohepatitis (NASH), and it is related to the development of MS. Lifestyle intervention, physical activity, and weight reduction represent the mainstay of NAFLD therapy. In particular, a catch-up growth reduction could decrease the risk to develop MS and NAFLD.
In this paper, we outline clinical and experimental evidences of the association between IUGR, metabolic syndrome, insulin resistance, and NAFLD and discuss on a possible management to avoid the risk of MS in adulthood. |
| format | Article |
| id | doaj-art-540a25126c3d4962904995e8edb43522 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-540a25126c3d4962904995e8edb435222025-02-03T01:31:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/269853269853Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in ChildrenAnna Alisi0Nadia Panera1Carlo Agostoni2Valerio Nobili3Liver Research Unit, Bambino Gesù Children's Hospital and Research Institute, 00165 Rome, ItalyLiver Research Unit, Bambino Gesù Children's Hospital and Research Institute, 00165 Rome, ItalyDepartment of Maternal and Pediatric Sciences, Fondazione IRCCS Ca' Granda—Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, ItalyLiver Research Unit, Bambino Gesù Children's Hospital and Research Institute, 00165 Rome, ItalyIntrauterine growth retardation (IUGR), the most important cause of perinatal mortality and morbidity, is defined as a foetal growth less than normal for the population, often used as synonym of small for gestational age (SGA). Studies demonstrated the relationships between metabolic syndrome (MS) and birthweight. This study suggested that, in children, adolescents, and adults born SGA, insulin resistance could lead to other metabolic disorders: type 2 diabetes (DM2), dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). NAFLD may evolve to nonalcoholic steatohepatitis (NASH), and it is related to the development of MS. Lifestyle intervention, physical activity, and weight reduction represent the mainstay of NAFLD therapy. In particular, a catch-up growth reduction could decrease the risk to develop MS and NAFLD. In this paper, we outline clinical and experimental evidences of the association between IUGR, metabolic syndrome, insulin resistance, and NAFLD and discuss on a possible management to avoid the risk of MS in adulthood.http://dx.doi.org/10.1155/2011/269853 |
| spellingShingle | Anna Alisi Nadia Panera Carlo Agostoni Valerio Nobili Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children International Journal of Endocrinology |
| title | Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children |
| title_full | Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children |
| title_fullStr | Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children |
| title_full_unstemmed | Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children |
| title_short | Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children |
| title_sort | intrauterine growth retardation and nonalcoholic fatty liver disease in children |
| url | http://dx.doi.org/10.1155/2011/269853 |
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