Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting

Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting

Abstract The reduction in plasma leptin levels is crucial for the brain to perceive negative energy balance and activate adaptive responses, including activating corticotrophin-releasing factor neurons in the paraventricular nucleus of the hypothalamus (CRFPVN). Notably, leptin receptor (Lepr) expre...

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Bibliographic Details
Main Authors: Nathalia Lopes Ferreira, Higor J. Fideles, Ana Beatriz Marcal, Ana Paula Brianezi, João Victor Silva Nani, André Souza Mecawi, Rodrigo Rorato
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
HPA axis
POMC
Lepr
Fasting
Cre-LoxP
DREADDs
Online Access:https://doi.org/10.1038/s41598-025-09990-0
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