The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine
Objective: To evaluate the pressor and mydriatic effects of different concentrations of tropicamide and phenylephrine eye drops: tropicamide 0.5% (Mydriacyl), phenylephrine hydrochloride 2.5% (Mydfrin), tropicamide-phenylephrine combination 0.5%/0.5% (Sanmyd-P), and self-prepared mixture (1:1 diluti...
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Philippine Academy of Ophthalmology
2005-03-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/426 |
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| author | Marion Alva Mesina-Bayana, MD Milagros H. Arroyo, MD |
| author_facet | Marion Alva Mesina-Bayana, MD Milagros H. Arroyo, MD |
| author_sort | Marion Alva Mesina-Bayana, MD |
| collection | DOAJ |
| description | Objective: To evaluate the pressor and mydriatic effects of different concentrations of tropicamide and phenylephrine eye drops: tropicamide 0.5% (Mydriacyl), phenylephrine hydrochloride 2.5% (Mydfrin), tropicamide-phenylephrine combination 0.5%/0.5% (Sanmyd-P), and self-prepared mixture (1:1 dilution) of commercially prepared tropicamide 0.5% and phenylephrine 2.5%.
Methods: A prospective, randomized, double-blind study was carried out involving 160 eyes of 80 patients who were randomly assigned into four groups to receive phenylephrine + tropicamide 0.5%/0.5% (Group A), tropicamide + phenylephrine 0.2%/1.25 (Group B), tropicamide 0.5% (Group C), or phenylephrine 2.5% (Group D). The main outcome measures were systolic, diastolic, and mean arterial pressures; pulse rate; and horizontal pupillary diameter determined at 10-, 20-, 30-, 45-, and 60-minute intervals postinstillation. Repeated measures analysis of variance and Tukey’s honestly significant difference were used to analyze outcomes.
Results: There was no significant increase in the systolic and diastolic blood pressure within each group and between groups. The mean increase or decrease in heart rate from baseline did not show a significant difference. Tropicamide-phenylephrine 0.5%/0.5% (Group A) and tropicamide-phenylephrine 0.25%/ 1.25% (Group B) yielded the highest mean increase in pupil size across time.
Conclusion: Tropicamide-phenylephrine 0.5%/0.5% and tropicamide-phenylephrine 0.25%/1.25% attained better dilation per unit time than the other treatment groups. No significant effect on blood pressure and heart rate was seen in all groups. |
| format | Article |
| id | doaj-art-5406595a892842f8a40f2df587710ee9 |
| institution | OA Journals |
| issn | 0031-7659 |
| language | English |
| publishDate | 2005-03-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-5406595a892842f8a40f2df587710ee92025-08-20T01:49:47ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592005-03-01301711426The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrineMarion Alva Mesina-Bayana, MD0Milagros H. Arroyo, MD1Department of Ophthalmology and Visual Sciences University of the Philippines Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines Philippine General Hospital Manila, PhilippinesObjective: To evaluate the pressor and mydriatic effects of different concentrations of tropicamide and phenylephrine eye drops: tropicamide 0.5% (Mydriacyl), phenylephrine hydrochloride 2.5% (Mydfrin), tropicamide-phenylephrine combination 0.5%/0.5% (Sanmyd-P), and self-prepared mixture (1:1 dilution) of commercially prepared tropicamide 0.5% and phenylephrine 2.5%. Methods: A prospective, randomized, double-blind study was carried out involving 160 eyes of 80 patients who were randomly assigned into four groups to receive phenylephrine + tropicamide 0.5%/0.5% (Group A), tropicamide + phenylephrine 0.2%/1.25 (Group B), tropicamide 0.5% (Group C), or phenylephrine 2.5% (Group D). The main outcome measures were systolic, diastolic, and mean arterial pressures; pulse rate; and horizontal pupillary diameter determined at 10-, 20-, 30-, 45-, and 60-minute intervals postinstillation. Repeated measures analysis of variance and Tukey’s honestly significant difference were used to analyze outcomes. Results: There was no significant increase in the systolic and diastolic blood pressure within each group and between groups. The mean increase or decrease in heart rate from baseline did not show a significant difference. Tropicamide-phenylephrine 0.5%/0.5% (Group A) and tropicamide-phenylephrine 0.25%/ 1.25% (Group B) yielded the highest mean increase in pupil size across time. Conclusion: Tropicamide-phenylephrine 0.5%/0.5% and tropicamide-phenylephrine 0.25%/1.25% attained better dilation per unit time than the other treatment groups. No significant effect on blood pressure and heart rate was seen in all groups.https://paojournal.com/index.php/pjo/article/view/426tropicamidephenylephrinemydriaticblood pressureheart rate |
| spellingShingle | Marion Alva Mesina-Bayana, MD Milagros H. Arroyo, MD The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine Philippine Journal of Ophthalmology tropicamide phenylephrine mydriatic blood pressure heart rate |
| title | The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine |
| title_full | The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine |
| title_fullStr | The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine |
| title_full_unstemmed | The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine |
| title_short | The pressor and mydriatic effects of tropicamide-phenylephrine combination, plain tropicamide, and plain phenylephrine |
| title_sort | pressor and mydriatic effects of tropicamide phenylephrine combination plain tropicamide and plain phenylephrine |
| topic | tropicamide phenylephrine mydriatic blood pressure heart rate |
| url | https://paojournal.com/index.php/pjo/article/view/426 |
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