Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study
Objectives To investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.Methods Data from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) from the Assessment...
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BMJ Publishing Group
2022-09-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/8/2/e002514.full |
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| author | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Victoria Navarro-Compán Diego Benavent Dafne Capelusnik |
| author_facet | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Victoria Navarro-Compán Diego Benavent Dafne Capelusnik |
| author_sort | Sofia Ramiro |
| collection | DOAJ |
| description | Objectives To investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.Methods Data from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) from the Assessment of SpondyloArthritis International Society (ASAS)-perSpA study were analysed. Associations between gender and disease activity (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Score (BASDAI), C-reactive protein (CRP)), function (Bath Ankylosing Spondylitis Functional Index (BASFI)) and overall health (ASAS Health Index (ASAS HI), European Quality of Life Five Dimension (EQ-5D)) outcomes were investigated. Multilevel multivariable linear mixed models adjusted for relevant confounders (and stratified by disease subtype in case of a relevant interaction) were used.Results In total, 65%, 10% and 25% of patients had axSpA, pSpA and PsA, respectively. axSpA was more frequent in males (68%), whereas pSpA and PsA were more frequent in females (53% and 52%, respectively). A significant interaction between gender and disease subtype was found for ASDAS, BASDAI and BASFI. While being female independently contributed to higher BASDAI across the three disease subtypes (with varying magnitude), female gender was only associated with higher ASDAS in pSpA (β (95% CI): 0.36 (0.15 to 0.58)) and PsA (0.25 (0.12 to 0.38)) but not in axSpA (0.016 (−0.07 to 0.11)). No associations were observed between gender and CRP levels. Female gender was associated with higher ASAS HI and EQ-5D, without differences across disease subtype.Conclusion Female gender is associated with less favourable outcome measures across the SpA spectrum. However, while female gender influences BASDAI across the three subtypes, ASDAS is associated with gender only in pSpA and PsA but not in axSpA. Therefore, ASDAS is an appropriate instrument both for females and males with axSpA. |
| format | Article |
| id | doaj-art-53ff73defa6a49a7816adbbaa6118e70 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | BMJ Publishing Group |
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| series | RMD Open |
| spelling | doaj-art-53ff73defa6a49a7816adbbaa6118e702025-02-08T05:50:11ZengBMJ Publishing GroupRMD Open2056-59332022-09-018210.1136/rmdopen-2022-002514Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA studySofia Ramiro0Maxime Dougados1Anna Molto2Clementina López-Medina3Victoria Navarro-Compán4Diego Benavent5Dafne Capelusnik6Department of Rheumatology, Zuyderland Medical Centre Heerlen, Heerlen, NetherlandsRheumatology, Hospital Cochin, Université Paris Descartes Faculté de Médecine, Paris, France21 Rheumatology, Hopital Cochin, paris, Ile de France, FranceMaimonides Biomedical Research Institute of Cordoba, University of Cordoba, Cordoba, SpainRheumatology, Hospital Universitario La Paz, Madrid, SpainRheumatology, Hospital Universitario La Paz, Madrid, SpainUniversiteit Maastricht Care and Public Health Research Institute, Maastricht, The NetherlandsObjectives To investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.Methods Data from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) from the Assessment of SpondyloArthritis International Society (ASAS)-perSpA study were analysed. Associations between gender and disease activity (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Score (BASDAI), C-reactive protein (CRP)), function (Bath Ankylosing Spondylitis Functional Index (BASFI)) and overall health (ASAS Health Index (ASAS HI), European Quality of Life Five Dimension (EQ-5D)) outcomes were investigated. Multilevel multivariable linear mixed models adjusted for relevant confounders (and stratified by disease subtype in case of a relevant interaction) were used.Results In total, 65%, 10% and 25% of patients had axSpA, pSpA and PsA, respectively. axSpA was more frequent in males (68%), whereas pSpA and PsA were more frequent in females (53% and 52%, respectively). A significant interaction between gender and disease subtype was found for ASDAS, BASDAI and BASFI. While being female independently contributed to higher BASDAI across the three disease subtypes (with varying magnitude), female gender was only associated with higher ASDAS in pSpA (β (95% CI): 0.36 (0.15 to 0.58)) and PsA (0.25 (0.12 to 0.38)) but not in axSpA (0.016 (−0.07 to 0.11)). No associations were observed between gender and CRP levels. Female gender was associated with higher ASAS HI and EQ-5D, without differences across disease subtype.Conclusion Female gender is associated with less favourable outcome measures across the SpA spectrum. However, while female gender influences BASDAI across the three subtypes, ASDAS is associated with gender only in pSpA and PsA but not in axSpA. Therefore, ASDAS is an appropriate instrument both for females and males with axSpA.https://rmdopen.bmj.com/content/8/2/e002514.full |
| spellingShingle | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Victoria Navarro-Compán Diego Benavent Dafne Capelusnik Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study RMD Open |
| title | Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study |
| title_full | Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study |
| title_fullStr | Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study |
| title_full_unstemmed | Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study |
| title_short | Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study |
| title_sort | does gender influence outcome measures similarly in patients with spondyloarthritis results from the asas perspa study |
| url | https://rmdopen.bmj.com/content/8/2/e002514.full |
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