Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states

Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states

Abstract Transcription factors (TFs) and transcriptional coregulators are emerging therapeutic targets. Gene regulatory networks (GRNs) can evaluate pharmacological agents and identify drivers of disease, but methods that rely solely on gene expression often neglect post-transcriptional modulation o...

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Main Authors: Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W. Siebel, M. Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62252-5
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