Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline
In this research, salbutamol sulphate (SAS) has been determined by a simple, rapid and sensitive spectrophotometric method. Salbutamol sulphate in this method is based on the coupling of SAS with diazotized ρ- bromoaniline reagent in alkaline medium of Triton X-100 (Tx) to form an orange azo dye whi...
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University of Baghdad, College of Science for Women
2019-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3941 |
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| author | Tamathir et al. |
| author_facet | Tamathir et al. |
| author_sort | Tamathir et al. |
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| description | In this research, salbutamol sulphate (SAS) has been determined by a simple, rapid and sensitive spectrophotometric method. Salbutamol sulphate in this method is based on the coupling of SAS with diazotized ρ- bromoaniline reagent in alkaline medium of Triton X-100 (Tx) to form an orange azo dye which is stable and water-soluble. The azo dye is exhibiting maximum absorption at 441 nm. A 10 - 800 µg of SAS is obeyed of Beer's law in a final volume of 20 ml, i.e., 0.5- 40 ppm with ε, the molar absorptivity of 48558 L.mol-1.cm-1 and Sandell's sensitivity index of 0.01188 µg.cm-2. This new method does not need solvent extraction or temperature control which is well applied to determine SAS in different types of pharmaceutical preparations. |
| format | Article |
| id | doaj-art-53f97d47fac34ff1b9ad266e3f9f898d |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-53f97d47fac34ff1b9ad266e3f9f898d2025-08-20T03:56:19ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862019-09-0116310.21123/bsj.16.3.610Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoanilineTamathir et al.In this research, salbutamol sulphate (SAS) has been determined by a simple, rapid and sensitive spectrophotometric method. Salbutamol sulphate in this method is based on the coupling of SAS with diazotized ρ- bromoaniline reagent in alkaline medium of Triton X-100 (Tx) to form an orange azo dye which is stable and water-soluble. The azo dye is exhibiting maximum absorption at 441 nm. A 10 - 800 µg of SAS is obeyed of Beer's law in a final volume of 20 ml, i.e., 0.5- 40 ppm with ε, the molar absorptivity of 48558 L.mol-1.cm-1 and Sandell's sensitivity index of 0.01188 µg.cm-2. This new method does not need solvent extraction or temperature control which is well applied to determine SAS in different types of pharmaceutical preparations.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3941Azo dye, diazotization coupling reaction, pharmaceuticals determination, spectrophotometric method, Triton X-100. |
| spellingShingle | Tamathir et al. Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline مجلة بغداد للعلوم Azo dye, diazotization coupling reaction, pharmaceuticals determination, spectrophotometric method, Triton X-100. |
| title | Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline |
| title_full | Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline |
| title_fullStr | Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline |
| title_full_unstemmed | Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline |
| title_short | Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline |
| title_sort | spectrophotometric assay of salbutamol sulphate in pharmaceutical preparations by coupling with diazotized ρ bromoaniline |
| topic | Azo dye, diazotization coupling reaction, pharmaceuticals determination, spectrophotometric method, Triton X-100. |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3941 |
| work_keys_str_mv | AT tamathiretal spectrophotometricassayofsalbutamolsulphateinpharmaceuticalpreparationsbycouplingwithdiazotizedrbromoaniline |