Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions
Purpose. To evaluate the peripapillary retinal nerve fiber layer (RNFL) thicknesses of patients treated with intravitreal Ozurdex implant due to branch retinal vein occlusion (BRVO) related macular edema (ME). Methods. Thirty-three eyes of 33 patients treated with Ozurdex implant due to ME associate...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/2050796 |
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| author | Muhammed Nurullah Bulut Yusuf Özertürk Ümit Çallı Güzide Akçay Ulviye Kıvrak Kezban Bulut |
| author_facet | Muhammed Nurullah Bulut Yusuf Özertürk Ümit Çallı Güzide Akçay Ulviye Kıvrak Kezban Bulut |
| author_sort | Muhammed Nurullah Bulut |
| collection | DOAJ |
| description | Purpose. To evaluate the peripapillary retinal nerve fiber layer (RNFL) thicknesses of patients treated with intravitreal Ozurdex implant due to branch retinal vein occlusion (BRVO) related macular edema (ME). Methods. Thirty-three eyes of 33 patients treated with Ozurdex implant due to ME associated with BRVO were included in the study. Ophthalmic examinations including determination of best corrected visual acuity (BCVA), measurement of intraocular pressure (IOP), and central macular thickness (CMT) and peripapillary RNFL assessment with optical coherence tomography (OCT) were performed before the injection of Ozurdex implant and during the 6-month follow-up period after the injection. Results. The mean age was 55.2 ± 7.4 (range: 40–68) years. The BCVAs were significantly increased and CMTs were significantly decreased at month 3 and month 6 visits compared to baseline values. The mean IOP was significantly increased from baseline at day 1, week 1, and month 1 visits (p1=0.008, p2=0.018, and p3=0.022, resp.). The average and inferior quadrant peripapillary RNFL thicknesses were significantly reduced at month 6 control visit compared to baseline values (both p<0.001). Conclusions. Ozurdex implant improved the BCVA and reduced the CMT in the eyes with RVO related ME. However, IOP elevations occurred within the first month after the injection and the average and inferior quadrant RNFL thinning was found six months after the injection. Further controlled studies are warranted. |
| format | Article |
| id | doaj-art-53edc760e4304d11a49b09a55016c063 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-53edc760e4304d11a49b09a55016c0632025-02-03T05:43:45ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/20507962050796Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein OcclusionsMuhammed Nurullah Bulut0Yusuf Özertürk1Ümit Çallı2Güzide Akçay3Ulviye Kıvrak4Kezban Bulut5Dr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyDr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyDr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyDr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyDr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyDr. Lütfi Kırdar Kartal Training and Research Hospital, Eye Department, Istanbul, TurkeyPurpose. To evaluate the peripapillary retinal nerve fiber layer (RNFL) thicknesses of patients treated with intravitreal Ozurdex implant due to branch retinal vein occlusion (BRVO) related macular edema (ME). Methods. Thirty-three eyes of 33 patients treated with Ozurdex implant due to ME associated with BRVO were included in the study. Ophthalmic examinations including determination of best corrected visual acuity (BCVA), measurement of intraocular pressure (IOP), and central macular thickness (CMT) and peripapillary RNFL assessment with optical coherence tomography (OCT) were performed before the injection of Ozurdex implant and during the 6-month follow-up period after the injection. Results. The mean age was 55.2 ± 7.4 (range: 40–68) years. The BCVAs were significantly increased and CMTs were significantly decreased at month 3 and month 6 visits compared to baseline values. The mean IOP was significantly increased from baseline at day 1, week 1, and month 1 visits (p1=0.008, p2=0.018, and p3=0.022, resp.). The average and inferior quadrant peripapillary RNFL thicknesses were significantly reduced at month 6 control visit compared to baseline values (both p<0.001). Conclusions. Ozurdex implant improved the BCVA and reduced the CMT in the eyes with RVO related ME. However, IOP elevations occurred within the first month after the injection and the average and inferior quadrant RNFL thinning was found six months after the injection. Further controlled studies are warranted.http://dx.doi.org/10.1155/2016/2050796 |
| spellingShingle | Muhammed Nurullah Bulut Yusuf Özertürk Ümit Çallı Güzide Akçay Ulviye Kıvrak Kezban Bulut Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions Journal of Ophthalmology |
| title | Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions |
| title_full | Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions |
| title_fullStr | Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions |
| title_full_unstemmed | Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions |
| title_short | Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions |
| title_sort | evaluation of peripapillary nerve fiber layer after dexamethasone implantation ozurdex in branch retinal vein occlusions |
| url | http://dx.doi.org/10.1155/2016/2050796 |
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