How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review.
<h4>Background and purpose</h4>Recovery after intracerebral haemorrhage (ICH) is often slower than ischemic stroke. Despite this, ICH research often quantifies recovery using the same outcome measures obtained at the same timepoints as ischemic stroke. The primary objective of this scopi...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253964&type=printable |
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| author | Sara Massicotte Ronda Lun Vignan Yogendrakumar Brian Dewar Hee Sahng Chung Ricarda Konder Holly Yim Alexandra Davis Dean Fergusson Michel Shamy Dar Dowlatshahi |
| author_facet | Sara Massicotte Ronda Lun Vignan Yogendrakumar Brian Dewar Hee Sahng Chung Ricarda Konder Holly Yim Alexandra Davis Dean Fergusson Michel Shamy Dar Dowlatshahi |
| author_sort | Sara Massicotte |
| collection | DOAJ |
| description | <h4>Background and purpose</h4>Recovery after intracerebral haemorrhage (ICH) is often slower than ischemic stroke. Despite this, ICH research often quantifies recovery using the same outcome measures obtained at the same timepoints as ischemic stroke. The primary objective of this scoping review is to map the existing literature to determine when and how outcomes are being measured in prospective studies of recovery after ICH.<h4>Methods</h4>We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Web of Science from inception to November 2019, for prospective studies that included patients with ICH. Two investigators independently screened the studies and extracted data around timing and type of outcome assessment.<h4>Results</h4>Among the 9761 manuscripts reviewed, 395 met inclusion criteria, of which 276 were observational studies and 129 were interventional studies that enrolled 66274 patients. Mortality was assessed in 93% of studies. Functional outcomes were assessed in 85% of studies. The most frequently used functional assessment tool was the modified Rankin Scale (mRS) (60%), followed by the National Institute of Health Stroke Severity Scale (22%) and Barthel Index (21%). The most frequent timepoint at which mortality was assessed was 90 days (41%), followed by 180 days (18%) and 365 days (12%), with 2% beyond 1 year. The most frequent timepoint used for assessing mRS was 90 days (62%), followed by 180 days (21%) and 365 days (17%).<h4>Conclusion</h4>While most prospective ICH studies report mortality and functional outcomes only at 90 days, a significant proportion do so at 1 year and beyond. Our results support the feasibility of collecting long-term outcome data to optimally assess recovery in ICH. |
| format | Article |
| id | doaj-art-53ed1ac5bc2044c89926c813ab23c2ac |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-53ed1ac5bc2044c89926c813ab23c2ac2025-02-05T05:32:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01166e025396410.1371/journal.pone.0253964How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review.Sara MassicotteRonda LunVignan YogendrakumarBrian DewarHee Sahng ChungRicarda KonderHolly YimAlexandra DavisDean FergussonMichel ShamyDar Dowlatshahi<h4>Background and purpose</h4>Recovery after intracerebral haemorrhage (ICH) is often slower than ischemic stroke. Despite this, ICH research often quantifies recovery using the same outcome measures obtained at the same timepoints as ischemic stroke. The primary objective of this scoping review is to map the existing literature to determine when and how outcomes are being measured in prospective studies of recovery after ICH.<h4>Methods</h4>We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Web of Science from inception to November 2019, for prospective studies that included patients with ICH. Two investigators independently screened the studies and extracted data around timing and type of outcome assessment.<h4>Results</h4>Among the 9761 manuscripts reviewed, 395 met inclusion criteria, of which 276 were observational studies and 129 were interventional studies that enrolled 66274 patients. Mortality was assessed in 93% of studies. Functional outcomes were assessed in 85% of studies. The most frequently used functional assessment tool was the modified Rankin Scale (mRS) (60%), followed by the National Institute of Health Stroke Severity Scale (22%) and Barthel Index (21%). The most frequent timepoint at which mortality was assessed was 90 days (41%), followed by 180 days (18%) and 365 days (12%), with 2% beyond 1 year. The most frequent timepoint used for assessing mRS was 90 days (62%), followed by 180 days (21%) and 365 days (17%).<h4>Conclusion</h4>While most prospective ICH studies report mortality and functional outcomes only at 90 days, a significant proportion do so at 1 year and beyond. Our results support the feasibility of collecting long-term outcome data to optimally assess recovery in ICH.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253964&type=printable |
| spellingShingle | Sara Massicotte Ronda Lun Vignan Yogendrakumar Brian Dewar Hee Sahng Chung Ricarda Konder Holly Yim Alexandra Davis Dean Fergusson Michel Shamy Dar Dowlatshahi How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. PLoS ONE |
| title | How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. |
| title_full | How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. |
| title_fullStr | How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. |
| title_full_unstemmed | How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. |
| title_short | How outcomes are measured after spontaneous intracerebral hemorrhage: A systematic scoping review. |
| title_sort | how outcomes are measured after spontaneous intracerebral hemorrhage a systematic scoping review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253964&type=printable |
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