Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms
Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/704564 |
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| author | Ola M. Abdallah |
| author_facet | Ola M. Abdallah |
| author_sort | Ola M. Abdallah |
| collection | DOAJ |
| description | Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5–45 𝜇g mL−1 for guaifenesin and 10–80 𝜇g mL−1 for dropropizine. Both drugs were also successfully determined in their dosage forms. |
| format | Article |
| id | doaj-art-53e8984ff73941429a5d294bf5cfd66d |
| institution | OA Journals |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
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| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-53e8984ff73941429a5d294bf5cfd66d2025-08-20T02:05:25ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792010-01-01201010.1155/2010/704564704564Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage FormsOla M. Abdallah0Faculty of Pharmacy , October University for Modern Sciences and Arts, El Wahat Road, 6th October City, EgyptGuaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5–45 𝜇g mL−1 for guaifenesin and 10–80 𝜇g mL−1 for dropropizine. Both drugs were also successfully determined in their dosage forms.http://dx.doi.org/10.1155/2010/704564 |
| spellingShingle | Ola M. Abdallah Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms International Journal of Analytical Chemistry |
| title | Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms |
| title_full | Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms |
| title_fullStr | Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms |
| title_full_unstemmed | Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms |
| title_short | Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms |
| title_sort | sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms |
| url | http://dx.doi.org/10.1155/2010/704564 |
| work_keys_str_mv | AT olamabdallah sensitivespectrophotometricmethodforquantitationofguaifenesinanddropropizineintheirdosageforms |