Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin
Background: Isotretinoin, a first-generation nonaromatic retinoid approved in 1973 for severe nodulocystic acne treatment in the United States, has historically been associated with mucocutaneous adverse events. Case: The case involves a 22-year-old male with chronic plaque psoriasis who, after eigh...
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| Format: | Article |
| Language: | Indonesian |
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Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga
2024-11-01
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| Series: | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
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| Online Access: | https://e-journal.unair.ac.id/BIKK/article/view/54281 |
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| _version_ | 1846140765060726784 |
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| author | Daisy Ahluwalia Shikha Bansal Kuchana Prathibha Abhishek Lachyan |
| author_facet | Daisy Ahluwalia Shikha Bansal Kuchana Prathibha Abhishek Lachyan |
| author_sort | Daisy Ahluwalia |
| collection | DOAJ |
| description | Background: Isotretinoin, a first-generation nonaromatic retinoid approved in 1973 for severe nodulocystic acne treatment in the United States, has historically been associated with mucocutaneous adverse events. Case: The case involves a 22-year-old male with chronic plaque psoriasis who, after eight weeks of isotretinoin use, experienced swelling, pain, and bleeding in the periungual area of multiple fingers. Dermoscopic examination and follow-up assessments, including images, demonstrate the progression and eventual complete resolution of the periungual pyogenic granuloma following discontinuation of isotretinoin and topical application of fusidic acid and betamethasone combination. Discussion: The discussion delves into potential mechanisms linking isotretinoin to increased skin fragility and granulation tissue development, drawing on insights from experts like Baran and Piraccini. Additionally, we explore the role of angiogenic factors, particularly vascular endothelial growth factor (VEGF), in the context of psoriasis and its potential contribution to the development of pyogenic granuloma, with the aim of providing a comprehensive understanding of the underlying processes leading to this unique adverse event. Conclusion: In conclusion, this case report underscores the importance of recognizing and promptly addressing rare adverse events associated with medication errors. The successful resolution of the periungual pyogenic granuloma highlights the significance of timely intervention and appropriate management strategies in mitigating adverse outcomes. |
| format | Article |
| id | doaj-art-53e384997289404e97f06020c7217aad |
| institution | Kabale University |
| issn | 1978-4279 2549-4082 |
| language | Indonesian |
| publishDate | 2024-11-01 |
| publisher | Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| spelling | doaj-art-53e384997289404e97f06020c7217aad2024-12-05T04:49:18ZindDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)1978-42792549-40822024-11-0136322222410.20473/bikk.V36.3.2024.222-22452443Periungual Pyogenic Granuloma in Multiple Nails due to IsotretinoinDaisy Ahluwalia0Shikha Bansal1Kuchana Prathibha2Abhishek Lachyan3https://orcid.org/0000-0002-4339-2070Department of Dermatology & STD and Apex Regional STD Centre, Safdarjung Hospital, New Delhi, IndiaDepartment of Dermatology & STD and Apex Regional STD Centre, Safdarjung Hospital, New Delhi, IndiaDepartment of Dermatology & STD and Apex Regional STD Centre, Safdarjung Hospital, New Delhi, India2Apex Regional STD Centre, Safdarjung Hospital, New Delhi, IndiaBackground: Isotretinoin, a first-generation nonaromatic retinoid approved in 1973 for severe nodulocystic acne treatment in the United States, has historically been associated with mucocutaneous adverse events. Case: The case involves a 22-year-old male with chronic plaque psoriasis who, after eight weeks of isotretinoin use, experienced swelling, pain, and bleeding in the periungual area of multiple fingers. Dermoscopic examination and follow-up assessments, including images, demonstrate the progression and eventual complete resolution of the periungual pyogenic granuloma following discontinuation of isotretinoin and topical application of fusidic acid and betamethasone combination. Discussion: The discussion delves into potential mechanisms linking isotretinoin to increased skin fragility and granulation tissue development, drawing on insights from experts like Baran and Piraccini. Additionally, we explore the role of angiogenic factors, particularly vascular endothelial growth factor (VEGF), in the context of psoriasis and its potential contribution to the development of pyogenic granuloma, with the aim of providing a comprehensive understanding of the underlying processes leading to this unique adverse event. Conclusion: In conclusion, this case report underscores the importance of recognizing and promptly addressing rare adverse events associated with medication errors. The successful resolution of the periungual pyogenic granuloma highlights the significance of timely intervention and appropriate management strategies in mitigating adverse outcomes.https://e-journal.unair.ac.id/BIKK/article/view/54281adverse eventsisotretinoinpyogenic granuloma |
| spellingShingle | Daisy Ahluwalia Shikha Bansal Kuchana Prathibha Abhishek Lachyan Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) adverse events isotretinoin pyogenic granuloma |
| title | Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin |
| title_full | Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin |
| title_fullStr | Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin |
| title_full_unstemmed | Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin |
| title_short | Periungual Pyogenic Granuloma in Multiple Nails due to Isotretinoin |
| title_sort | periungual pyogenic granuloma in multiple nails due to isotretinoin |
| topic | adverse events isotretinoin pyogenic granuloma |
| url | https://e-journal.unair.ac.id/BIKK/article/view/54281 |
| work_keys_str_mv | AT daisyahluwalia periungualpyogenicgranulomainmultiplenailsduetoisotretinoin AT shikhabansal periungualpyogenicgranulomainmultiplenailsduetoisotretinoin AT kuchanaprathibha periungualpyogenicgranulomainmultiplenailsduetoisotretinoin AT abhisheklachyan periungualpyogenicgranulomainmultiplenailsduetoisotretinoin |