Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical cohe...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/8025337 |
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| _version_ | 1849406345169600512 |
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| author | Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello |
| author_facet | Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello |
| author_sort | Andrew Tirsi |
| collection | DOAJ |
| description | Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch’s membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area. Results. Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p≤0.004). All pattern electroretinogram parameters significantly correlated with Bruch’s membrane opening-minimum rim width sectors—temporal superior and nasal inferior (r = 0.400, p=0.039)—and retinal nerve fiber layer sectors—superior, nasal superior, and inferior (r ≥ 0.428, p≤0.026). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p=0.003, and B = 0.160 (95% CI: 0.056, 0.265), p=0.004), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch’s membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p=0.031, and B = 129.024 (95% CI: 9.589, 248.460), p=0.035), respectively. All Bruch’s membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p≤0.045). Conclusion. PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma. |
| format | Article |
| id | doaj-art-53e1a424306f4dd2b468a46640e44ea0 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-53e1a424306f4dd2b468a46640e44ea02025-08-20T03:36:25ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/80253378025337Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc AreaAndrew Tirsi0Vasiliki Gliagias1Julie Moehringer2Derek Orshan3Sofia Tello4Peter Derr5Sung Chul Park6Stephen A Obstbaum7Celso Tello8Manhattan Eye Ear and Throat Hospital, New York, NY 10065, USADonald and Barbara Zucker School of Medicine at Hofstra University/Northwell Health, Hempstead, NY 11549, USASandford H. Calhoun High School, Merrick, NY 11566, USANew York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11545, USARye High School, Rye, NY 10580, USADiopsys Inc., Pine Brook, NJ 07058, USAManhattan Eye Ear and Throat Hospital, New York, NY 10065, USAManhattan Eye Ear and Throat Hospital, New York, NY 10065, USAManhattan Eye Ear and Throat Hospital, New York, NY 10065, USAPurpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch’s membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area. Results. Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p≤0.004). All pattern electroretinogram parameters significantly correlated with Bruch’s membrane opening-minimum rim width sectors—temporal superior and nasal inferior (r = 0.400, p=0.039)—and retinal nerve fiber layer sectors—superior, nasal superior, and inferior (r ≥ 0.428, p≤0.026). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p=0.003, and B = 0.160 (95% CI: 0.056, 0.265), p=0.004), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch’s membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p=0.031, and B = 129.024 (95% CI: 9.589, 248.460), p=0.035), respectively. All Bruch’s membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p≤0.045). Conclusion. PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma.http://dx.doi.org/10.1155/2021/8025337 |
| spellingShingle | Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area Journal of Ophthalmology |
| title | Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area |
| title_full | Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area |
| title_fullStr | Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area |
| title_full_unstemmed | Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area |
| title_short | Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area |
| title_sort | pattern electroretinogram parameters are associated with optic nerve morphology in preperimetric glaucoma after adjusting for disc area |
| url | http://dx.doi.org/10.1155/2021/8025337 |
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