Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention
Extrahepatic biliary atresia (EHBA) is a leading cause of neonatal cholestasis, often resulting in end-stage cirrhosis and portal hypertension without early diagnosis and treatment. This report highlights the importance of timely intervention, describing a 6-day-old male newborn diagnosed with EHBA...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241311115 |
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| author | Mortada H.F. El-Shabrawi Gamal Eltagy Mohamed Qinawy Mohammed Am Oshi Amjad Algethami Nawaf A Alhujayri Shaker S Alharthi Abdullah M Alelyani Naglaa M Kamal |
| author_facet | Mortada H.F. El-Shabrawi Gamal Eltagy Mohamed Qinawy Mohammed Am Oshi Amjad Algethami Nawaf A Alhujayri Shaker S Alharthi Abdullah M Alelyani Naglaa M Kamal |
| author_sort | Mortada H.F. El-Shabrawi |
| collection | DOAJ |
| description | Extrahepatic biliary atresia (EHBA) is a leading cause of neonatal cholestasis, often resulting in end-stage cirrhosis and portal hypertension without early diagnosis and treatment. This report highlights the importance of timely intervention, describing a 6-day-old male newborn diagnosed with EHBA who underwent successful Kasai portoenterostomy at 9 days of age. While the procedure is typically performed within the first 60 days of life, this exceptionally early intervention led to significantly improved outcomes. Postoperative recovery was marked by bilirubin normalization within 2 months and steady improvement in liver function tests, demonstrating the advantages of early surgery. The procedure involved creating a Roux-en-Y hepatic portojejunostomy to restore bile flow, preventing progression to biliary cirrhosis. Early intervention achieved effective bile drainage and substantial clinical improvement. At the 1-year follow-up, the infant displayed normal growth and liver function. This case supports the hypothesis that performing Kasai portoenterostomy earlier than current guidelines recommend may lead to better outcomes. It underscores the need for vigilant neonatal care to recognize early signs of cholestasis and enable prompt surgical intervention. Early diagnosis and intervention can preserve liver function, potentially delaying or preventing the need for liver transplantation. |
| format | Article |
| id | doaj-art-53e092f7459849de8b9bf3538cbf6772 |
| institution | Kabale University |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-53e092f7459849de8b9bf3538cbf67722025-02-09T06:03:38ZengSAGE PublishingJournal of International Medical Research1473-23002025-02-015310.1177/03000605241311115Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt interventionMortada H.F. El-ShabrawiGamal EltagyMohamed QinawyMohammed Am OshiAmjad AlgethamiNawaf A AlhujayriShaker S AlharthiAbdullah M AlelyaniNaglaa M KamalExtrahepatic biliary atresia (EHBA) is a leading cause of neonatal cholestasis, often resulting in end-stage cirrhosis and portal hypertension without early diagnosis and treatment. This report highlights the importance of timely intervention, describing a 6-day-old male newborn diagnosed with EHBA who underwent successful Kasai portoenterostomy at 9 days of age. While the procedure is typically performed within the first 60 days of life, this exceptionally early intervention led to significantly improved outcomes. Postoperative recovery was marked by bilirubin normalization within 2 months and steady improvement in liver function tests, demonstrating the advantages of early surgery. The procedure involved creating a Roux-en-Y hepatic portojejunostomy to restore bile flow, preventing progression to biliary cirrhosis. Early intervention achieved effective bile drainage and substantial clinical improvement. At the 1-year follow-up, the infant displayed normal growth and liver function. This case supports the hypothesis that performing Kasai portoenterostomy earlier than current guidelines recommend may lead to better outcomes. It underscores the need for vigilant neonatal care to recognize early signs of cholestasis and enable prompt surgical intervention. Early diagnosis and intervention can preserve liver function, potentially delaying or preventing the need for liver transplantation.https://doi.org/10.1177/03000605241311115 |
| spellingShingle | Mortada H.F. El-Shabrawi Gamal Eltagy Mohamed Qinawy Mohammed Am Oshi Amjad Algethami Nawaf A Alhujayri Shaker S Alharthi Abdullah M Alelyani Naglaa M Kamal Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention Journal of International Medical Research |
| title | Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention |
| title_full | Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention |
| title_fullStr | Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention |
| title_full_unstemmed | Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention |
| title_short | Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention |
| title_sort | early kasai portoenterostomy in a 9 day old newborn with extrahepatic biliary atresia a case report highlighting improved prognosis with prompt intervention |
| url | https://doi.org/10.1177/03000605241311115 |
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